Results 21 to 30 of about 116,963 (259)

Urology Residency Directors' Awareness of Association between α-Adrenergic Antagonists and Floppy Iris Syndrome and Practice Patterns Regarding Prophylactic α-Adrenergic Antagonists

Journal of Academic Ophthalmology, 2019
Purpose The use of prophylactic α-adrenergic receptor antagonists prior to surgery is associated with reduced postoperative urinary retention. However, α-adrenergic receptor antagonists have been associated with intraoperative floppy iris syndrome (IFIS).
David Cui, Gaytri Gupta-Elera, Ingrid U. Scott   +2 more
doaj   +1 more source

Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo. [PDF]

PLoS ONE, 2010
RATIONALE: Previous in vitro research demonstrated that ascorbate enhances potency and duration of activity of agonists binding to alpha 1 adrenergic and histamine receptors.
Patrick F Dillon, Robert Root-Bernstein, N Edward Robinson, William M Abraham, Catherine Berney   +4 more
doaj   +1 more source

Augmented β2-adrenergic signaling dampens the neuroinflammatory response following ischemic stroke and increases stroke size

Journal of Neuroinflammation, 2019
Background Ischemic stroke provokes a neuroinflammatory response and simultaneously promotes release of epinephrine and norepinephrine by the sympathetic nervous system.
Kendra J. Lechtenberg, Scott T. Meyer, Janelle B. Doyle, Todd C. Peterson, Marion S. Buckwalter   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

BIOMARKER IDENTIFICATION IN BREAST CANCER: BETA-ADRENERGIC RECEPTOR SIGNALING AND PATHWAYS TO THERAPEUTIC RESPONSE

Computational and Structural Biotechnology Journal, 2013
Recent preclinical studies have associated beta-adrenergic receptor (β-AR) signaling with breast cancer pathways such as progression and metastasis. These findings have been supported by clinical and epidemiological studies which examined the effect of ...
Liana E. Kafetzopoulou, David J. Boocock, Gopal Krishna R. Dhondalay, Desmond G. Powe, Graham R. Ball   +4 more
doaj   +1 more source

Involvement of Toll-Like Receptor 4 in Decreased Vasopressor Response Following Trauma/Hemorrhagic Shock

Critical Care Explorations, 2021
OBJECTIVES:. Refractory vascular failure due to the inability of vascular smooth muscle to respond to vasoconstrictors such as phenylephrine is a final common pathway for severe circulatory shock of any cause, including trauma/hemorrhagic shock ...
Rafi Mazor, PhD, Fernando Dos Santos, PhD, Joyce B. Li, MSc, Federico Aletti, PhD, Geert Schmid-Schonbein, PhD, Erik B. Kistler, MD, PhD   +5 more
doaj   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Adrenergic Autoantibody‐Induced Postural Tachycardia Syndrome in Rabbits

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Previous studies have demonstrated that functional autoantibodies to adrenergic receptors may be involved in the pathogenesis of postural tachycardia syndrome.
Hongliang Li, Gege Zhang, Liping Zhou, Zachary Nuss, Marci Beel, Brendon Hines, Taylor Murphy, Jonathan Liles, Ling Zhang, David C. Kem, Xichun Yu   +10 more
doaj   +1 more source

β-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver. [PDF]

PLoS ONE, 2014
Autophagy recently has been shown to be involved in normal hepatic function and in pathological conditions such as non-alcoholic fatty liver disease. Adrenergic signalling also is an important regulator of hepatic metabolism and function.
Benjamin L Farah, Rohit A Sinha, Yajun Wu, Brijesh K Singh, Jin Zhou, Boon-Huat Bay, Paul M Yen   +6 more
doaj   +1 more source

Role of β-adrenergic receptors in insulin resistance: Induction or protection?

Zagazig Journal of Pharmaceutical Sciences, 2021
β Adrenergic receptors, in particular β2 subtype, are key regulators of glucose homeostasis. Previous studies showed that activation of hepatic and adipose tissue β adrenergic receptors mediates insulin desensitizing effects.
Wael Ibrahim , Islam Ibrahim, Amr Mahmoud , Mona Abdelaziz   +3 more
doaj   +1 more source