Results 1 to 10 of about 92,128 (162)
Selectivity and Maximum Response of Vibegron and Mirabegron for β3-Adrenergic Receptors
Current Therapeutic Research, 2022 : Background: The β3-adrenergic agonists vibegron and mirabegron have shown favorable safety profiles and efficacy for the treatment of overactive bladder.
Benjamin M. Brucker, MD +3 more
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Pharmaceuticals, 2022 This paper proposes the design of combination opioid–adrenergic tethered compounds to enhance efficacy and specificity, lower dosage, increase duration of activity, decrease side effects, and reduce risk of developing tolerance and/or addiction ...
Robert Root-Bernstein
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Ligands of Adrenergic Receptors: A Structural Point of View
Biomolecules, 2021 Adrenergic receptors are G protein-coupled receptors for epinephrine and norepinephrine. They are targets of many drugs for various conditions, including treatment of hypertension, hypotension, and asthma.
Yiran Wu, Liting Zeng, Suwen Zhao
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Life, 2021 Cross-talk between opioid and adrenergic receptors is well-characterized and involves second messenger systems, the formation of receptor heterodimers, and the presence of extracellular allosteric binding regions for the complementary ligand; however ...
Robert Root-Bernstein, Beth Churchill
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Alpha adrenergic receptors in clinical practice – Present and future
Acta Marisiensis - Seria Medica, 2022 In this review we discuss the adrenergic pathways for alpha 1 and alpha 2 receptors and the current as well as potential future medication targeting these receptors.
Lechsner Patrick, Ban Erika-Gyongyi
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Role of β-adrenergic receptors in insulin resistance: Induction or protection?
Zagazig Journal of Pharmaceutical Sciences, 2021 β Adrenergic receptors, in particular β2 subtype, are key regulators of glucose homeostasis. Previous studies showed that activation of hepatic and adipose tissue β adrenergic receptors mediates insulin desensitizing effects.
Wael Ibrahim +3 more
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Opposing effects of α2- and β-adrenergic receptor stimulation on quiescent neural precursor cell activity and adult hippocampal neurogenesis. [PDF]
PLoS ONE, 2014 Norepinephrine regulates latent neural stem cell activity and adult hippocampal neurogenesis, and has an important role in modulating hippocampal functions such as learning, memory and mood.
Dhanisha J Jhaveri +7 more
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Role of adrenergic receptors in shock
Frontiers in Physiology, 2023 Shock is a severe, life-threatening medical condition with a high mortality rate worldwide. All four major categories of shock (along with their various subtypes)—hypovolemic, distributive, cardiogenic, and obstructive, involve a dramatic mismatch ...
Mathew Geevarghese +5 more
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The Role of Alpha-2 Adrenergic Receptors in Anti-ulcer Activity
Eurasian Journal of Medicine, 2019 Although peptic ulcer disease has long been recognized, the proposed mechanisms of its etiopathogenesis change every year. This review shows that gastric ulcers have a significant relationship with alpha-2 adrenergic receptors. The aggravating factors of
Halis Suleyman
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α1-Adrenergic Receptors in Neurotransmission, Synaptic Plasticity, and Cognition
Frontiers in Pharmacology, 2020 α1-adrenergic receptors are G-Protein Coupled Receptors that are involved in neurotransmission and regulate the sympathetic nervous system through binding and activating the neurotransmitter, norepinephrine, and the neurohormone, epinephrine.
Dianne M. Perez
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