Results 101 to 110 of about 169,892 (299)

Impact of noradrenergic inhibition on neuroinflammation and pathophysiology in mouse models of Alzheimer’s disease

Journal of Neuroinflammation
Norepinephrine (NE) modulates cognitive function, arousal, attention, and responses to novelty and stress, and it also regulates neuroinflammation. We previously demonstrated behavioral and immunomodulatory effects of beta-adrenergic pharmacology in ...
Andrew K. Evans, Heui Hye Park, Claire E. Woods, Rachel K. Lam, Daniel Ryskamp Rijsketic, Christine Xu, Emily K. Chu, Peter Ciari, Sarah Blumenfeld, Laura M. Vidano, Nay Lui Saw, Boris D. Heifets, Mehrdad Shamloo   +12 more
doaj   +1 more source

Aripiprazole-induced priapism

Industrial Psychiatry Journal, 2016
Priapism is a urologic emergency representing a true disorder of penile erection that persists beyond or is unrelated to sexual interest or stimulation.
Satya K Trivedi, Ajish G Mangot, Siddhartha Sinha   +2 more
doaj   +1 more source

Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. [PDF]

, 2004
We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Both single and chronic administration of imipramine potently shortened immobility in naive rats during forced-swim testing.
Araki, Hiroaki, Gomita, Yutaka, Kitamura, Yoshihisa, Nagatani, Tadashi, Shibata, Kazuhiko, Takao, Katsuyuki   +5 more
core   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Multiple Biogenic Amine Receptor Types Modulate Spider, Cupiennius salei, Mechanosensory Neurons

Frontiers in Physiology, 2018
The biogenic amines octopamine (OA), tyramine (TA), dopamine (DA), serotonin (5-HT), and histamine (HA) affect diverse physiological and behavioral processes in invertebrates, but recent findings indicate that an additional adrenergic system exists in at
Vaishnavi Sukumar, Hongxia Liu, Shannon Meisner, Andrew S. French, Päivi H. Torkkeli   +4 more
doaj   +1 more source

The Role of the Sympathetic Nervous System in the Hypothermic Effect of d-Fenfluramine [PDF]

, 2002
Experiments in this dissertation were conducted to characterize the effects of d-fenfluramine on body temperature and the mechanisms by which d-fenfluramine alter body temperature.
Subramanian, Srividya
core   +1 more source

Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic receptor and anti-obesity and anti-diabetic profiles [PDF]

, 2018
Indexación: Scopus.Acknowledgments: This work was supported by FONDECYT No. 11130701. We would also like to thank fDoTr CthLeafbr efeora vthaeil afrbeilei tayvoafiltahbeilsitoyf towfa trheer seoqfutwireadret orecqaulciureladt etothcealAcuDla(thet ttph:e/
Andrades-Lagos, J., Campanini-Salinas, J., Lorca, M., Mella, J., Morales-Verdejo, C., Recabarren-Gajardo, G., Soto-Delgado, J., Vásquez-Velásquez, D.   +7 more
core   +2 more sources

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, EarlyView.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

Programming the Optoelectronic Properties of Atomically Precise Gold Nanoclusters Using the Conformational Landscape of Intrinsically Disordered Proteins

Chemistry – A European Journal, EarlyView.
ABSTRACT The rational design of hybrid nanomaterials with precisely controlled properties remains a central challenge in materials science. While atomically precise gold nanoclusters (Au‐NCs) offer molecule‐like control over a metallic core, tuning their optoelectronic behavior via surface engineering is often empirically driven.
Santiago Rodriguez, Sylvain Kumanski, Zeineb Ayed, Aurélie Fournet, Charlène Bouanchaud, Amin Sagar, Frédéric Allemand, Vladimir A. Baulin, Ute Resch‐Genger, Juan Cortés, Nathalie Sibille, Fabien Chirot, Karl David Wegner, Rodolphe Antoine, Xavier Le Guével, Pau Bernadó   +15 more
wiley   +1 more source

The Different Effects of Noradrenaline on Rhabdomyosarcoma and Ewing’s Sarcoma Cancer Hallmarks—Implications for Exercise Oncology

Onco
Background: Exercise has beneficial effects on cancer and its treatment, but the underlying mechanisms are poorly understood. Some studies have linked the positive impact of exercise to catecholamine signaling.
Peter Weeber, Stephanie Bremer, Jonas Haferanke, Carla Regina, Martin Schönfelder, Henning Wackerhage, Irene von Luettichau   +6 more
doaj   +1 more source