β-Adrenergic receptors as immunomodulators in T cells: mechanisms of neuroimmune crosstalk and pathophysiological implications [PDF]
Molecular MedicineRegulation of T cell function by the sympathetic nervous system via β-adrenergic receptors is a pivotal research focus in neuroimmunology, with most studies centered on β2-adrenergic receptors. However, the roles of other subtypes remain unclear.
Junyan Yao +4 more
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Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies [PDF]
BiomoleculesNeurodegenerative diseases are currently among the most devastating diseases with no effective disease-modifying drugs in the market, with Alzheimer’s disease (AD) being the most prevalent.
Androulla N. Miliotou +2 more
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Comparative Study of the Effects of Drugs Targeting Adrenergic Receptors on the Early Life Stages of Zebrafish [PDF]
ToxicsOwing to the presence of drugs targeting adrenergic receptors in aquatic ecosystems, considerable attention has been directed towards their environmental distribution and fate in recent decades.
Junsheng Lv +5 more
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A (Alpha1-Adrenergic Receptors), B (Blocking Alpha1-Adrenergic Receptors), C (Catecholamines) [PDF]
JACC: Basic to Translational ScienceRajika Roy, PhD, Walter J. Koch, PhD
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Selectivity and Maximum Response of Vibegron and Mirabegron for β3-Adrenergic Receptors
Current Therapeutic Research, 2022 : Background: The β3-adrenergic agonists vibegron and mirabegron have shown favorable safety profiles and efficacy for the treatment of overactive bladder.
Benjamin M. Brucker, MD +3 more
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Pharmaceuticals, 2022 This paper proposes the design of combination opioid–adrenergic tethered compounds to enhance efficacy and specificity, lower dosage, increase duration of activity, decrease side effects, and reduce risk of developing tolerance and/or addiction ...
Robert Root-Bernstein
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Ligands of Adrenergic Receptors: A Structural Point of View
Biomolecules, 2021 Adrenergic receptors are G protein-coupled receptors for epinephrine and norepinephrine. They are targets of many drugs for various conditions, including treatment of hypertension, hypotension, and asthma.
Yiran Wu, Liting Zeng, Suwen Zhao
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Life, 2021 Cross-talk between opioid and adrenergic receptors is well-characterized and involves second messenger systems, the formation of receptor heterodimers, and the presence of extracellular allosteric binding regions for the complementary ligand; however ...
Robert Root-Bernstein, Beth Churchill
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Alpha adrenergic receptors in clinical practice – Present and future
Acta Marisiensis - Seria Medica, 2022 In this review we discuss the adrenergic pathways for alpha 1 and alpha 2 receptors and the current as well as potential future medication targeting these receptors.
Lechsner Patrick, Ban Erika-Gyongyi
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Role of β-adrenergic receptors in insulin resistance: Induction or protection?
Zagazig Journal of Pharmaceutical Sciences, 2021 β Adrenergic receptors, in particular β2 subtype, are key regulators of glucose homeostasis. Previous studies showed that activation of hepatic and adipose tissue β adrenergic receptors mediates insulin desensitizing effects.
Wael Ibrahim +3 more
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