Results 1 to 10 of about 130,584 (225)

Management of Urinary Incontinence Following Radical Prostatectomy: Challenges and Solutions

Therapeutics and Clinical Risk Management, 2023
Pietro Castellan,1 Simone Ferretti,2 Giulio Litterio,2 Michele Marchioni,1,2 Luigi Schips1,2 1Department of Urology, ASL02 Abruzzo, Chieti, Italy; 2Department of Medical, Oral and Biotechnological Sciences, G.
Castellan P, Ferretti S, Litterio G, Marchioni M, Schips L   +4 more
doaj   +2 more sources

Non-Selective PDE4 Inhibition Induces a Rapid and Transient Decrease of Serum Potassium in Mice

Biology, 2022
The analysis of blood samples from mice treated with the PDE4 inhibitor Roflumilast revealed an unexpected reduction in serum potassium levels, while sodium and chloride levels were unaffected.
Abigail Boyd, Peter Lochmaier, Daniel Irelan, Edward Fiedler, Ji Young Lee, Brian Fouty, Lina Abou Saleh, Wito Richter   +7 more
doaj   +1 more source

Identification of factors associated with the efficacy of atomoxetine in adult attention‐deficit/hyperactivity disorder

Neuropsychopharmacology Reports, 2022
Aim Atomoxetine (ATX) is a non‐central stimulant and a standard treatment for adult attention‐deficit/hyperactivity disorder (ADHD). The long‐term efficacy of Atomoxetine is about 40% at 6 months.
Tsutomu Nagai, Tatsuya Kurihara, Hiroaki Koya, Yukako Nakano, Satoru Sugisawa, Takehiko Sambe, Keiko Kishimoto, Mari Kogo, Haruhisa Ota, Akira Iwanami, Naoki Uchida   +10 more
doaj   +1 more source

Regulatory effect of connexin 43 on basal Ca2+ signaling in rat ventricular myocytes. [PDF]

PLoS ONE, 2012
BACKGROUND: It has been found that gap junction-associated intracellular Ca(2+) [Ca(2+)](i) disturbance contributes to the arrhythmogenesis and hyperconstriction in diseased heart.
Chen Li, Qingli Meng, Xinfeng Yu, Xian Jing, Pingxiang Xu, Dali Luo   +5 more
doaj   +1 more source

A machine learning and network framework to discover new indications for small molecules.

PLoS Computational Biology, 2020
Drug repurposing, identifying novel indications for drugs, bypasses common drug development pitfalls to ultimately deliver therapies to patients faster. However, most repurposing discoveries have been led by anecdotal observations (e.g.
Coryandar Gilvary, Jamal Elkhader, Neel Madhukar, Claire Henchcliffe, Marcus D Goncalves, Olivier Elemento   +5 more
doaj   +1 more source

NCLX prevents cell death during adrenergic activation of the brown adipose tissue

bioRxiv, 2018
A sharp increase in mitochondrial Ca 2+ marks the activation of brown adipose tissue (BAT) thermogenesis, yet the mechanisms preventing Ca 2+ deleterious effects are poorly understood.
Essam A. Assali, Anthony E. Jones, Michaela Veliova, Mahmoud Taha, Nathanael Miller, Michael Shum, Marcus F. Oliveira, G. Las, M. Liesa, I. Sekler, O. Shirihai   +10 more
semanticscholar   +1 more source

Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion

ACS Chemical Biology, 2022
Background: Lower survival rates for many cancer types correlate with changes in nuclear size/scaling in a tumor-type/tissue-specific manner. Hypothesizing that such changes might confer an advantage to tumor cells, we aimed at the identification of ...
S. Tollis, A. Rizzotto, N. Pham, Sonja Koivukoski, A. Sivakumar, S. Shave, Jan Wildenhain, N. Zuleger, Jeremy T Keys, Jayne Culley, Yijing Zheng, J. Lammerding, N. Carragher, V. Brunton, Leena Latonen, M. Auer, M. Tyers, E. C. Schirmer   +17 more
semanticscholar   +1 more source

Inhibition of Brain Swelling after Ischemia-Reperfusion by β-Adrenergic Antagonists: Correlation with Increased K+ and Decreased Ca2+ Concentrations in Extracellular Fluid

BioMed Research International, 2014
Infarct size and brain edema following ischemia/reperfusion are reduced by inhibitors of the Na+, K+, 2Cl−, and water cotransporter NKCC1 and by β 1-adrenoceptor antagonists. NKCC1 is a secondary active transporter, mainly localized in astrocytes, driven
D. Song, Junnan Xu, Ting Du, Enzhi Yan, L. Hertz, W. Walz, Liang Peng   +6 more
semanticscholar   +1 more source

Alpha 1-adrenergic stimulation of arachidonic acid release and metabolism in a rat thyroid cell line. Mediation of cell replication by prostaglandin E2.

Journal of Biological Chemistry, 1986
The rat thyroid cell line, FRTL-5, expresses an alpha 1-adrenergic receptor when exposed to thyrotropin. We have found that occupation of this alpha 1-adrenergic receptor by norepinephrine stimulated the release of [3H]arachidonic acid from prelabeled ...
R. Burch, A. Luini, D. Mais, D. Corda, J. Vanderhoek, L. Kohn, J. Axelrod   +6 more
semanticscholar   +1 more source

Pharmacotherapy in Stress Urinary Incontinence; A Literature Review

Current Urology Reports
Stress urinary incontinence (SUI) is a commonly observed condition in females, as well as in males who have undergone prostatectomy. Despite the significant progress made in surgical techniques, pharmacotherapy has not yielded substantial outcomes within
Seyed Sajjad Tabei, W. Baas, A. Mahdy
semanticscholar   +1 more source