Results 1 to 10 of about 1,396,034 (289)

Pediatric adrenocortical carcinoma

Frontiers in Endocrinology, 2022
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy of the adrenal gland with an unfavorable prognosis. It is rare in the pediatric population, with an incidence of 0.2-0.3 patients per million in patients under 20 years old.
Maran Ilanchezhian, Diana Grace Varghese, John W. Glod, Karlyne M. Reilly, Brigitte C. Widemann, Yves Pommier, Rosandra N. Kaplan, Jaydira Del Rivero   +7 more
doaj   +4 more sources

Adrenocortical Carcinoma [PDF]

Cancers, 2021
Adrenocortical carcinoma (ACC) is an extremely rare disease, the incidence of which is 0 [...].
A. Berruti, G. Tiberio, S. Sigala
semanticscholar   +7 more sources

DNA hypermethylation driven by DNMT1 and DNMT3A favors tumor immune escape contributing to the aggressiveness of adrenocortical carcinoma

Clinical Epigenetics, 2023
Background Adrenocortical carcinoma is rare and aggressive endocrine cancer of the adrenal gland. Within adrenocortical carcinoma, a recently described subtype characterized by a CpG island methylator phenotype (CIMP) has been associated with an ...
Gwenneg Kerdivel, Floriane Amrouche, Marie-Ange Calmejane, Floriane Carallis, Juliette Hamroune, Constanze Hantel, Jérôme Bertherat, Guillaume Assié, Valentina Boeva   +8 more
doaj   +2 more sources

Quercetin-Rich Extracts from Onions (Allium cepa) Play Potent Cytotoxicity on Adrenocortical Carcinoma Cell Lines, and Quercetin Induces Important Anticancer Properties

Pharmaceuticals, 2022
Adrenocortical carcinoma (ACC) is a rare subtype of cancer, with a poor prognosis in children and adults. Mitotane is the only approved adrenolytic drug for the treatment of ACC, which has controversies regarding its efficacy and side effects on patients.
Alan A. Veiga, Ana Carolina Irioda, Bassam F. Mogharbel, Sandro J. R. Bonatto, Lauro M. Souza   +4 more
doaj   +2 more sources

Adrenocortical Carcinoma: Updates of Clinical and Pathological Features after Renewed World Health Organisation Classification and Pathology Staging

Biomedicines, 2021
Adrenocortical carcinoma (ACC) is a heterogenous group of diseases with different clinical behaviour between adult and paediatric patients. In addition, three histological variants, oncocytic, myxoid and sarcomatoid are noted on the recent World Health ...
Alfred King-yin Lam
doaj   +2 more sources

Frontiers in Systemic Therapy for Unresectable or Metastatic Adrenocortical Carcinoma: Harnessing Novel Therapeutic Approaches [PDF]

Clinical Medicine Insights: Oncology
Adrenocortical carcinoma is a rare, aggressive endocrine malignancy with limited effective systemic therapy options and an overall poor prognosis for unresectable or metastatic disease.
Adam E Singer, Nikhita Kathuria-Prakash, David Shabsovich, Lizette Garcia, Leland Damron, Allan J Pantuck, Alexandra Drakaki   +6 more
doaj   +2 more sources

An Excellent Clinical and Radiological Response Pattern to Pembrolizumab in a Patient With Metastatic Adrenocortical Carcinoma and Lynch Syndrome [PDF]

IJU Case Reports
Introduction The prognosis of unresectable metastatic adrenocortical carcinoma is very poor. We report a case of Lynch syndrome accompanying metastatic adrenocortical carcinoma treated with pembrolizumab.
Yuki Shimozawa, Yosuke Yasuda, Emiko Sugawara, Ryosuke Oki, Kosuke Takemura, Tetsuya Urasaki, Ryo Fujiwara, Noboru Numao, Junji Yonese, Takeshi Yuasa   +9 more
doaj   +2 more sources

CDK1 serves as a therapeutic target of adrenocortical carcinoma via regulating epithelial–mesenchymal transition, G2/M phase transition, and PANoptosis

Journal of Translational Medicine, 2022
Background Adrenocortical carcinoma (ACC) is an extremely rare, aggressive tumor with few effective therapeutic options or drugs. Mitotane (Mtn), which is the only authorized therapeutic drug, came out in 1970 and is still the only first-line treatment ...
Li-wen Ren, Yihui Yang, Wan Li, Xiang-jin Zheng, Jin-yi Liu, Sha Li, Han Yang, Yizhi Zhang, Binbin Ge, Sen Zhang, W. Fu, Dexin Dong, Guanhua Du, Jinhua Wang   +13 more
semanticscholar   +1 more source

A hypoxia risk score for prognosis prediction and tumor microenvironment in adrenocortical carcinoma

Frontiers in Genetics, 2022
Background: Adrenocortical carcinoma (ACC) is a rare malignant endocrine tumor derived from the adrenal cortex. Because of its highly aggressive nature, the prognosis of patients with adrenocortical carcinoma is not impressive. Hypoxia exists in the vast
Yuanyuan Deng, Huihuang Li, Jinglan Fu, Ying Pu, Ying Zhang, Shijing Chen, Shiyu Tong, Huixia Liu   +7 more
doaj   +1 more source

Endocrine and Neuroendocrine Tumors Special Issue—Checkpoint Inhibitors for Adrenocortical Carcinoma and Metastatic Pheochromocytoma and Paraganglioma: Do They Work?

Cancers, 2022
Simple Summary In the past decade, the landscape of cancer treatment has radically changed after the introduction of immunotherapy. Adrenocortical carcinoma and metastatic pheochromocytoma/paraganglioma are rare cancers with limited responses to ...
C. Jimenez, Gustavo Armaiz-Peña, P. Dahia, Yang Lu, R. Toledo, J. Varghese, M. Habra   +6 more
semanticscholar   +1 more source