Results 171 to 180 of about 1,223,943 (215)
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FETAL AND NEWBORN ADRENOCORTICAL TUMORS
Fetal and Pediatric Pathology, 2010Adrenocortical tumors occur less often in the fetus and newborn than later in life. The purpose of this study was to focus on the fetus and newborn in an attempt to determine the various ways these tumors differ in their biologic behavior, pathology, clinical presentation and response to therapy from those occurring in the older child and adolescent ...
Hart Isaacs
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Outcome of adrenocortical tumors in children
Journal of Pediatric Surgery, 2008This study reviews adrenocortical tumors in children to determine factors that significantly affect outcome.An institutional review board-approved retrospective review from 1976 to 2005 identified 23 patients younger than 19 years old with histologic confirmation of adrenocortical carcinoma (ACC) and adenomas.The mean age of the 23 children was 9.0 +/-
Christopher R Moir +2 more
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Pathogenesis of benign adrenocortical tumors
Best Practice & Research Clinical Endocrinology & Metabolism, 2010Most adrenocortical tumors (ACT) are benign unilateral adrenocortical adenomas, often discovered incidentally. Exceptionally, ACT are bilateral. However bilateral ACT have been very helpful to progress in the pathophysiology of ACT. Although most ACT are of sporadic origin, they may also be part of syndromic and/or hereditary disorders.
Lionel Groussin, Jérome Bertherat
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Adrenocortical tumors in children
Seminars in Pediatric Surgery, 2020Adrenocortical neoplasms are rare in childhood. Unlike their adult counterparts, they are often hormonally active and malignant. Despite being uncommon, adrenocortical neoplasms in children have significant associated morbidity and require complete surgical resection for effective management.
Zachary J, Kastenberg, Eric R, Scaife
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The Genetics of Adrenocortical Tumors
Endocrinology and Metabolism Clinics of North America, 2015Advances in genomics accelerated greatly progress in the study of the genetics adrenocortical tumors. Bilateral nodular hyperplasias causing Cushing's syndrome are frequently caused by germline alterations leading to cAMP/PKA pathway activation (micronodular) and ARMC5 inactivation (macronodular).
Stéphanie, Espiard, Jérôme, Bertherat
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Adrenocortical tumors in childhood
Pediatric Surgery International, 2003Adrenocortical tumors (ACT) are rare in childhood. Determination of malignant potential is difficult. To assess the presentation, clinical behaviour, and histology of these tumors in our center, the records of nine patients with ACTs between 1989 and 2000 were analyzed. The age, sex, clinical presentation, investigations, treatment, follow-up data, and
K L, Narasimhan +6 more
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Adrenocortical tumors in children
Journal of Pediatric Surgery, 2001Etiopathogenesis and management of pediatric adrenocortical tumors (ACTs) is still obscure because of the limited number of cases. The aim of this study is to present a clear picture of the entire spectrum of pediatric ACTs by reviewing one of the largest noncollected pediatric series treated in a single medical center.Records of children treated for ...
Tanyel, FERİDUN CAHİT +3 more
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Dysregulation of microRNAs in adrenocortical tumors
Molecular and Cellular Endocrinology, 2012MicroRNAs (miRNAs) are short non-coding RNAs that are involved in the epigenetic regulation of cellular processes. Different malignancies are often associated with the deregulation of specific sets of miRNAs. The prognosis of adrenocortical cancers (ACCs) is very poor as compared to adrenocortical adenomas (ACAs), and even within ACCs there are cases ...
Singh, Puneet +7 more
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A Diagnostic Approach to Adrenocortical Tumors
Surgical Pathology Clinics, 2019Adrenocortical tumors range from primary bilateral micronodular or macronodular forms of adrenocortical disease to conventional adrenocortical adenomas and carcinomas. Accurate classification of these neoplasms is critical given the varied pathogenesis, clinical behavior, and outcome of these different lesions.
Anjelica, Hodgson +2 more
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Hyperandrogenism and Adrenocortical Tumors
2019Androgen-secreting tumors are a rare cause of hyperandrogenism of adrenal origin. Although these tumors are identified in less than 2% of patients, the prevalence of adrenocortical carcinomas is relevant (2/3 of the cases). Those tumors are associated with simultaneous elevation of several androgens, mainly androstenedione, DHEAS, and testosterone, in ...
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