Results 31 to 40 of about 20,049 (168)

Occurrence of Neuroblastoma among TP53 p.R337H Carriers. [PDF]

PLoS ONE, 2015
The high incidence of adrenocortical tumors and choroid plexus carcinoma in children from South and Southeastern regions of Brazil is associated with the germline p.R337H mutation of TP53 gene.
Ana Luiza Seidinger, Fernanda Paschoal Fortes, Maria José Mastellaro, Izilda Aparecida Cardinalli, Lilian Girotto Zambaldi, Simone Santos Aguiar, José Andrés Yunes   +6 more
doaj   +1 more source

Alterations of Phosphodiesterases in Adrenocortical Tumors [PDF]

Frontiers in Endocrinology, 2016
Alterations in the cyclic (c)AMP-dependent signaling pathway have been implicated in the majority of benign adrenocortical tumors (ACTs) causing Cushing syndrome (CS). Phosphodiesterases (PDEs) are enzymes that regulate cyclic nucleotide levels, including cyclic adenosine monophosphate (cAMP).
Hannah-Shmouni, Fady, Faucz, Fabio R., Stratakis, Constantine A.   +2 more
openaire   +3 more sources

Mouse Models Recapitulating Human Adrenocortical Tumors: What is lacking?

Frontiers in Endocrinology, 2016
Adrenal cortex tumors are divided into benign forms such as primary hyperplasias and adrenocortical adenomas (ACAs), and malignant forms or adrenocortical carcinomas (ACCs). Primary hyperplasias are rare causes of ACTH-independent hypercortisolism.
Felicia Leccia, Marie Batisse-Lignier, Marie Batisse-Lignier, Isabelle Sahut-Barnola, Pierre Val, A-Marie Lefrançois Martinez, Antoine Martinez   +6 more
doaj   +1 more source

Congenital adrenal hyperplasia with associated giant adrenal myelolipoma, testicular adrenal rest tumors and primary pigmented nodular adrenocortical disease: A case report and brief review of the literature

Radiology Case Reports, 2022
Congenital adrenal hyperplasia is an autosomal recessive disease most commonly associated with 21-hydroxylase deficiency, an enzyme integral in the biosynthesis of mineralocorticoids and glucocorticoids.
Aaron Jacobson, DO, M. Eng., Elaine Koberlein, BS, Alan Thomay, MD, Cara B Lombard, MD, Ayodele Adelanwa, MD, Dhairya A Lakhani, MD, Kelly T. Smith, MD, MS   +6 more
doaj   +1 more source

Adrenocortical Carcinoma Presenting with Signs of Acute Abdomen

Case Reports in Surgery, 2013
Background. Adrenocortical carcinomas represent rare malignancies. In cases of hormone-secreting tumors, the hormone in excess determines the nearly diagnostic clinical presentation.
Dimitrios Symeonidis, Ioannis Chatzinikolaou, Georgios Koukoulis, Ioannis Mamaloudis, Konstantinos Tepetes   +4 more
doaj   +1 more source

MicroRNAs as potential biomarkers in adrenocortical cancer: progress and challenges

Frontiers in Endocrinology, 2016
Adrenocortical carcinoma is a rare malignancy with poor prognosis and limited therapeutic options. Over the last decade, pan-genomic analyses of genetic and epigenetic alterations and genome-wide expression profile studies allowed major advances in the ...
Nadia eCHERRADI, Nadia eCHERRADI, Nadia eCHERRADI   +2 more
doaj   +1 more source

Acquisition order of Ras and p53 gene alterations defines distinct adrenocortical tumor phenotypes. [PDF]

PLoS Genetics, 2012
Sporadic adrenocortical carcinomas (ACC) are rare endocrine neoplasms with a dismal prognosis. By contrast, benign tumors of the adrenal cortex are common in the general population. Whether benign tumors represent a separate entity or are in fact part of
Maryline Herbet, Aude Salomon, Jean-Jacques Feige, Michaël Thomas   +3 more
doaj   +1 more source

Molecular markers of adrenocortical tumors [PDF]

Journal of Surgical Oncology, 2012
AbstractAdrenocortical tumors are common and incidentally discovered in up to 14% of axial imaging studies performed for other indications. Most of these tumors are nonfunctioning but may require removal because of the risk of adrenocortical carcinoma.
Meenu, Jain, Nesrin, Rechache, Electron, Kebebew   +2 more
openaire   +2 more sources

Single nucleotide polymorphism array profiling of adrenocortical tumors--evidence for an adenoma carcinoma sequence?

PLoS ONE, 2013
Adrenocortical tumors consist of benign adenomas and highly malignant carcinomas with a still incompletely understood pathogenesis. A total of 46 adrenocortical tumors (24 adenomas and 22 carcinomas) were investigated aiming to identify novel genes ...
Cristina L Ronchi, Silviu Sbiera, Ellen Leich, Katharina Henzel, Andreas Rosenwald, Bruno Allolio, Martin Fassnacht   +6 more
doaj   +1 more source

A Very Rare Reason for Hyperandrogenism: Adrenal Tumor Case

Bagcilar Medical Bulletin, 2023
Adrenal tumors are very rare causes of hyperandrogenism. Androgensecreting adrenal tumors are usually malignant; however, benign tumors have also been described in women. Adrenocortical carcinoma is very rare with incidence of 1 2 million per year.
Nurşen Kurtoğlu Aksoy, Hakan Gürarslan, Gül Gizem Pamuk   +2 more
doaj   +1 more source