Results 131 to 140 of about 1,089,127 (271)

The Pathway to Proof‐of‐Concept for BNC210, a Negative Allosteric Modulator of the Alpha‐7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease

Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.
Abstract BNC210 is an investigational small molecule selective negative allosteric modulator of the alpha‐7 nicotinic acetylcholine receptor (α7 nAChR). It is an anxiolytic compound with a novel mechanism of action. In a series of Phase 1 clinical trials in healthy volunteers, psychometric test batteries showed that BNC210 did not cause attention ...
Paul Rolan, Elizabeth Doolin, Dharam Paul, Julia Crossman, Michael Odontiadis, Philippe Danjou, Mark Smith, Spyros Papapetropoulos   +7 more
wiley   +1 more source

Hypothalamic–Pituitary–Thyroid and Adrenal Axis Modulation in Response to Fetal Porcine Reproductive and Respiratory Virus Infection

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
This study investigates the impact of fetal porcine reproductive and respiratory virus (PRRSV) infection on the Hypothalamic–Pituitary‐Thyroid/Adrenal axes. We report that infection‐induced nonthyroidal illness syndrome is associated with multitissue dysregulation of key genes involved in the control of endocrine function, providing insights into ...
Alyssa A. Smith, Glenn Hamonic, Graham S. Plastow, John C. S. Harding, J. Alex Pasternak   +4 more
wiley   +1 more source

Large-scale comparison of two immunoassays for adrenocorticotropic hormone in human plasma. [PDF]

Sci Rep
Li Y, Louie JZ, Burgess TE, Bare LA, McPhaul MJ.   +4 more
europepmc   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Cushing Disease Mimicking Ectopic Adrenocorticotropic Hormone-Secreting Disease. [PDF]

AACE Endocrinol Diabetes
Fisher DL, Fraenkel M, Baraf L.
europepmc   +1 more source

Pneumoperitoneum in two cats treated with trilostane for hypercortisolism

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract This report describes two cases of pneumoperitoneum in cats receiving treatment for hypercortisolism and diabetes mellitus. Both cats presented with abdominal distention and lethargy and diagnoses of pneumoperitoneum were radiographically confirmed.
Nicholas James Kelly, Armando Sánchez‐Lara, Mike E. Herrtage, Hannah Wong, Andre Kortum   +4 more
wiley   +1 more source

A Case of Metastatic Renal Cell Carcinoma Developing Isolated Adrenocorticotropic Hormone (ACTH) Deficiency During Nivolumab Therapy. [PDF]

Cureus
Enoki M, Yamanaka K, Kawashima A, Fukuhara S, Nonomura N.   +4 more
europepmc   +1 more source

ADRENOCORTICOTROPIC HORMONE IN HUMAN PLASMA* [PDF]

Journal of Clinical Investigation, 1962
V K, VANCE, W J, REDDY, D H, NELSON, G W, THORN   +3 more
openaire   +2 more sources

Isolated adrenocorticotropic hormone deficiency possibly caused by nivolumab in a metastatic melanoma patient

Journal of dermatology (Print), 2017
T. Fujimura, Y. Kambayashi, S. Furudate, Aya Kakizaki, T. Hidaka, T. Haga, A. Hashimoto, R. Morimoto, S. Aiba   +8 more
semanticscholar   +1 more source

Recurrent haemorrhage, due to vitamin K‐dependent coagulopathy, as the primary presenting complaint in a dog with naturally occurring hypoadrenocorticism

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 5‐year‐old male neutered standard poodle, presented with recurrent gingival margin haemorrhage and associated prolongations in prothrombin time and activated partial thromboplastin time, with repeatable demonstration of clinical (bleeding) and laboratory (prothrombin time, activated partial thromboplastin time) resolution with, and relapse ...
Jenny Reeve, Aiden Pang
wiley   +1 more source