Results 21 to 30 of about 23,058 (210)

Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics

open access: yesFrontiers in Behavioral Neuroscience, 2015
Recent studies have indicated that the serotonin receptor subtype 7 (5-HT7R) plays a crucial role in shaping neuronal morphology during embryonic and early postnatal life.
Luisa eSperanza   +15 more
doaj   +1 more source

Pharmacological Rescue of the Brain Cortex Phenotype of Tbx1 Mouse Mutants: Significance for 22q11.2 Deletion Syndrome

open access: yesFrontiers in Molecular Neuroscience, 2021
ObjectivesTbx1 mutant mice are a widely used model of 22q11.2 deletion syndrome (22q11.2DS) because they manifest a broad spectrum of physical and behavioral abnormalities that is similar to that found in 22q11.2DS patients.
Ilaria Favicchia   +6 more
doaj   +1 more source

Engineering a Correlated Narrow‐Gap Semiconductor: Effects of Ga Substitution in EuZn2P2

open access: yesAdvanced Electronic Materials, EarlyView.
ABSTRACT The effect of Ga substitution on the electronic, magnetic, and low‐energy responses of the Zintl phase EuZn2P2${\rm EuZn}_2 {\rm P}_2$ is investigated by electrical transport, electron spin resonance (ESR), and terahertz time‐domain spectroscopy (THz‐TDS). Incorporating Ga into EuZn2P2${\rm EuZn}_2 {\rm P}_2$ (EuZn1.8Ga0.2P2${\rm EuZn}_{1.8} {\
Mateus Dutra   +13 more
wiley   +1 more source

PPARG: Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues

open access: yesPPAR Research, 2010
Peroxisome proliferator-activated receptor gamma (PPARγ) is one of the most extensively studied ligand-inducible transcription factors (TFs), able to modulate its transcriptional activity through conformational changes.
Valerio Costa   +5 more
doaj   +1 more source

Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer

open access: yesDisease Models & Mechanisms, 2018
The TBX1 gene is haploinsufficient in 22q11.2 deletion syndrome (22q11.2DS), and genetic evidence from human patients and mouse models points to a major role of this gene in the pathogenesis of this syndrome.
Luna Simona Pane   +6 more
doaj   +1 more source

Identification of sixteen novel candidate genes for late onset Parkinson’s disease

open access: yesMolecular Neurodegeneration, 2021
Background Parkinson’s disease (PD) is a neurodegenerative movement disorder affecting 1–5% of the general population for which neither effective cure nor early diagnostic tools are available that could tackle the pathology in the early phase.
Alessandro Gialluisi   +17 more
doaj   +1 more source

Toward a Behavioral Reserve Model in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Neurology, EarlyView.
Objective Behavioral impairment is common in amyotrophic lateral sclerosis (ALS) and strongly affects autonomy, caregiver burden, and outcomes, yet predictors of vulnerability remain unclear. We investigated whether premorbid regulatory traits and socio‐educational exposures are associated with behavioral phenotypes in ALS within a behavioral reserve ...
Francesca Palumbo   +14 more
wiley   +1 more source

Review of CFD modelling techniques for single‐phase and multiphase flow in static mixers

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
This review synthesizes computational fluid dynamics (CFD) approaches for static mixers, linking hydrodynamics to pressure drop, particle/droplet distributions, mixing metrics, and heat‐transfer performance to guide modelling choices and design decisions. Abstract Static mixers enable compact and low‐energy intensification.
Jussan Jaeger   +7 more
wiley   +1 more source

Green Human Resource Management and ISO 14001: Toward Environmental Sustainability in Organizations

open access: yesHuman Resource Development Quarterly, EarlyView.
ABSTRACT The current climate change scenario imposes urgent challenges to different economic sectors around the world, requiring companies to adopt new strategies to achieve sustainable development goals (SDGs) while enhancing environmental awareness.
Eduardo Ortega   +2 more
wiley   +1 more source

Metabolic–Epigenetic Axis in Pluripotent State Transitions

open access: yesEpigenomes, 2019
Cell state transition (CST) occurs during embryo development and in adult life in response to different stimuli and is associated with extensive epigenetic remodeling.
Cristina D’Aniello   +3 more
doaj   +1 more source

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