Results 21 to 30 of about 22,784 (161)
PPARG: Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues
Peroxisome proliferator-activated receptor gamma (PPARγ) is one of the most extensively studied ligand-inducible transcription factors (TFs), able to modulate its transcriptional activity through conformational changes.
Valerio Costa +5 more
doaj +1 more source
The TBX1 gene is haploinsufficient in 22q11.2 deletion syndrome (22q11.2DS), and genetic evidence from human patients and mouse models points to a major role of this gene in the pathogenesis of this syndrome.
Luna Simona Pane +6 more
doaj +1 more source
Identification of sixteen novel candidate genes for late onset Parkinson’s disease
Background Parkinson’s disease (PD) is a neurodegenerative movement disorder affecting 1–5% of the general population for which neither effective cure nor early diagnostic tools are available that could tackle the pathology in the early phase.
Alessandro Gialluisi +17 more
doaj +1 more source
Metabolic–Epigenetic Axis in Pluripotent State Transitions
Cell state transition (CST) occurs during embryo development and in adult life in response to different stimuli and is associated with extensive epigenetic remodeling.
Cristina D’Aniello +3 more
doaj +1 more source
El evergetismo como mecanismo de legitimación del poder en la dinastía de los Antoninos
Todo gobierno requiere no solamente legalidad para presidir, sino también legitimidad; es por ello que toda autoridad pone en juego un complejo mecanismo de estrategias encargadas de mantenerla al frente del régimen.
Laura I. Zaccaria
doaj
En este artículo se analiza un rescripto de Adriano dirigido al concilium Baeticae donde se mencionan las penas que debían aplicarse a los cuatreros.
Pilar PAVÓN
doaj
The paxillin (PXN) protein is a key component of focal adhesions in which it primarily functions as a molecular scaffold to spatiotemporally integrate diverse signalling networks to transduce intracellular responses. In this study, using loss-of-function
O. Iacolare +6 more
doaj +1 more source
The highly fibrotic microenvironment of pancreatic ductal adenocarcinoma (PDAC) poses significant challenges for effective treatment, particularly in drug delivery and tumor progression.
Donatella Delle Cave +19 more
doaj +1 more source
Fios da trama poética de Adriano Espínola
Este ensaio pretende, na primeira parte, proceder a uma apresentação crítica da obra em progresso do poeta Adriano Espínola, inclusive levando em consideração a discussão atual sobre os caminhos da poesia brasileira contemporânea.
Antônio Donizeti PIRES
doaj +1 more source
Pharmacogenomics of Drug Response in Type 2 Diabetes: Toward the Definition of Tailored Therapies?
Type 2 diabetes is one of the major causes of mortality with rapidly increasing prevalence. Pharmacological treatment is the first recommended approach after failure in lifestyle changes.
Carla Pollastro +3 more
doaj +1 more source

