Results 21 to 30 of about 22,784 (161)

PPARG: Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues

PPAR Research, 2010
Peroxisome proliferator-activated receptor gamma (PPARγ) is one of the most extensively studied ligand-inducible transcription factors (TFs), able to modulate its transcriptional activity through conformational changes.
Valerio Costa, Maria Assunta Gallo, Francesca Letizia, Marianna Aprile, Amelia Casamassimi, Alfredo Ciccodicola   +5 more
doaj   +1 more source

Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer

Disease Models & Mechanisms, 2018
The TBX1 gene is haploinsufficient in 22q11.2 deletion syndrome (22q11.2DS), and genetic evidence from human patients and mouse models points to a major role of this gene in the pathogenesis of this syndrome.
Luna Simona Pane, Filomena Gabriella Fulcoli, Andrea Cirino, Alessandra Altomonte, Rosa Ferrentino, Marchesa Bilio, Antonio Baldini   +6 more
doaj   +1 more source

Identification of sixteen novel candidate genes for late onset Parkinson’s disease

Molecular Neurodegeneration, 2021
Background Parkinson’s disease (PD) is a neurodegenerative movement disorder affecting 1–5% of the general population for which neither effective cure nor early diagnostic tools are available that could tackle the pathology in the early phase.
Alessandro Gialluisi, Mafalda Giovanna Reccia, Nicola Modugno, Teresa Nutile, Alessia Lombardi, Luca Giovanni Di Giovannantonio, Sara Pietracupa, Daniela Ruggiero, Simona Scala, Stefano Gambardella, International Parkinson’s Disease Genomics Consortium (IPDGC), Licia Iacoviello, Fernando Gianfrancesco, Dario Acampora, Maurizio D’Esposito, Antonio Simeone, Marina Ciullo, Teresa Esposito   +17 more
doaj   +1 more source

Metabolic–Epigenetic Axis in Pluripotent State Transitions

Epigenomes, 2019
Cell state transition (CST) occurs during embryo development and in adult life in response to different stimuli and is associated with extensive epigenetic remodeling.
Cristina D’Aniello, Federica Cermola, Eduardo J. Patriarca, Gabriella Minchiotti   +3 more
doaj   +1 more source

El evergetismo como mecanismo de legitimación del poder en la dinastía de los Antoninos

Revista de Historia, 2015
Todo gobierno requiere no solamente legalidad para presidir, sino también legitimidad; es por ello que toda autoridad pone en juego un complejo mecanismo de estrategias encargadas de mantenerla al frente del régimen.
Laura I. Zaccaria
doaj  

De abigeis puniendis (D. 47, 14, 1; Coll. 11, 7, 13): el rescripto de Adriano sobre el robo de ganado en la Bética

Gerión, 2011
En este artículo se analiza un rescripto de Adriano dirigido al concilium Baeticae donde se mencionan las penas que debían aplicarse a los cuatreros.
Pilar PAVÓN
doaj  

Paxillin is crucial for thymus and parathyroid development by regulating the architecture of the third pharyngeal pouch endoderm

Cellular and Molecular Life Sciences
The paxillin (PXN) protein is a key component of focal adhesions in which it primarily functions as a molecular scaffold to spatiotemporally integrate diverse signalling networks to transduce intracellular responses. In this study, using loss-of-function
O. Iacolare, M. Bilio, A. Altomonte, O. Lanzetta, C. Turner, A. Baldini, D. Alfano   +6 more
doaj   +1 more source

TGF-β1-mediated downregulation of L1CAM in pancreatic ductal adenocarcinoma drives upregulation of collagen 17A1 and MMP2, facilitating tumor invasiveness and metastasis

Cell Death and Disease
The highly fibrotic microenvironment of pancreatic ductal adenocarcinoma (PDAC) poses significant challenges for effective treatment, particularly in drug delivery and tumor progression.
Donatella Delle Cave, Annalisa Di Domenico, Marco Fantuz, Marianna Ciotola, Maria Mangini, Silvia Buonaiuto, Brunella Corrado, Marco Corona, Federica Saracino, Gennaro Andolfi, Ilaria Di Biase, Antonio Cucciardi, Alessandro Carrer, Bruno Sainz, Teresa Pirozzi, Daniele Lo Re, Vincenza Colonna, Gabriella Minchiotti, Anna Chiara De Luca, Enza Lonardo   +19 more
doaj   +1 more source

Fios da trama poética de Adriano Espínola

Texto Poético, 2016
Este ensaio pretende, na primeira parte, proceder a uma apresentação crítica da obra em progresso do poeta Adriano Espínola, inclusive levando em consideração a discussão atual sobre os caminhos da poesia brasileira contemporânea.
Antônio Donizeti PIRES
doaj   +1 more source

Pharmacogenomics of Drug Response in Type 2 Diabetes: Toward the Definition of Tailored Therapies?

PPAR Research, 2015
Type 2 diabetes is one of the major causes of mortality with rapidly increasing prevalence. Pharmacological treatment is the first recommended approach after failure in lifestyle changes.
Carla Pollastro, Carmela Ziviello, Valerio Costa, Alfredo Ciccodicola   +3 more
doaj   +1 more source