Results 21 to 30 of about 108,991 (207)

The identification of H3F3A mutation in giant cell tumour of the clivus and the histological diagnostic algorithm of other clival lesions permit the differential diagnosis in this location

open access: yesBMC Cancer, 2018
Background Giant Cell Tumour of Bone (GCT) is a locally aggressive primary bone tumour that usually occurs at the epiphyses of the long bones of the appendicular skeleton with a tendency to recurrence.
Federica Scotto di Carlo   +4 more
doaj   +1 more source

DNMT3B Functions: Novel Insights From Human Disease

open access: yesFrontiers in Cell and Developmental Biology, 2018
DNA methylation plays important roles in gene expression regulation and chromatin structure. Its proper establishment and maintenance are essential for mammalian development and cellular differentiation.
Miriam Gagliardi   +3 more
doaj   +1 more source

Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics

open access: yesFrontiers in Behavioral Neuroscience, 2015
Recent studies have indicated that the serotonin receptor subtype 7 (5-HT7R) plays a crucial role in shaping neuronal morphology during embryonic and early postnatal life.
Luisa eSperanza   +15 more
doaj   +1 more source

Pharmacological Rescue of the Brain Cortex Phenotype of Tbx1 Mouse Mutants: Significance for 22q11.2 Deletion Syndrome

open access: yesFrontiers in Molecular Neuroscience, 2021
ObjectivesTbx1 mutant mice are a widely used model of 22q11.2 deletion syndrome (22q11.2DS) because they manifest a broad spectrum of physical and behavioral abnormalities that is similar to that found in 22q11.2DS patients.
Ilaria Favicchia   +6 more
doaj   +1 more source

Il valore della politica in Adriano Olivetti [PDF]

open access: yes, 2007
Quaderni della Fondazione Adriano Olivetti ...
Davide Cadeddu, D. Cadeddu
core  

PPARG: Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues

open access: yesPPAR Research, 2010
Peroxisome proliferator-activated receptor gamma (PPARγ) is one of the most extensively studied ligand-inducible transcription factors (TFs), able to modulate its transcriptional activity through conformational changes.
Valerio Costa   +5 more
doaj   +1 more source

Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer

open access: yesDisease Models & Mechanisms, 2018
The TBX1 gene is haploinsufficient in 22q11.2 deletion syndrome (22q11.2DS), and genetic evidence from human patients and mouse models points to a major role of this gene in the pathogenesis of this syndrome.
Luna Simona Pane   +6 more
doaj   +1 more source

Identification of sixteen novel candidate genes for late onset Parkinson’s disease

open access: yesMolecular Neurodegeneration, 2021
Background Parkinson’s disease (PD) is a neurodegenerative movement disorder affecting 1–5% of the general population for which neither effective cure nor early diagnostic tools are available that could tackle the pathology in the early phase.
Alessandro Gialluisi   +17 more
doaj   +1 more source

Metabolic–Epigenetic Axis in Pluripotent State Transitions

open access: yesEpigenomes, 2019
Cell state transition (CST) occurs during embryo development and in adult life in response to different stimuli and is associated with extensive epigenetic remodeling.
Cristina D’Aniello   +3 more
doaj   +1 more source

Adriano Olivetti e le Edizioni di Comunità (1946-1960) [PDF]

open access: yes, 2008
Quaderni della Fondazione Adriano Olivetti ...
Beniamino de' Liguori Carino
core  

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