Results 41 to 50 of about 23,058 (210)

Paxillin is crucial for thymus and parathyroid development by regulating the architecture of the third pharyngeal pouch endoderm

Cellular and Molecular Life Sciences
The paxillin (PXN) protein is a key component of focal adhesions in which it primarily functions as a molecular scaffold to spatiotemporally integrate diverse signalling networks to transduce intracellular responses. In this study, using loss-of-function
O. Iacolare, M. Bilio, A. Altomonte, O. Lanzetta, C. Turner, A. Baldini, D. Alfano   +6 more
doaj   +1 more source

Wavefront sensing at a high‐repetition‐rate X‐ray free‐electron laser

Journal of Synchrotron Radiation, EarlyView.
We demonstrate a fast, robust and sensor‐free approach to X‐ray speckle tracking that enables shot‐to‐shot wavefront characterization at high‐repetition‐rate X‐ray free‐electron lasers. Our measurements reveal a hierarchy of wavefront fluctuations indicative of instabilities in the accelerator and beamline optics at the European XFEL.Wavefront ...
Trey Guest, Patrik Vagovič, Luigi Adriano, Johan Bielecki, Sarlota Birnsteinova, Rita Graceffa, Jayanath Koliyadu, Kaye Morgan, Hiiro Moriyama, Daniel Mosko, Grant van Riessen, Kristian Sabol, Tokushi Sato, Peter Szeles, Zane Taylor, Jozef Uličný, Richard Bean, Adrian P. Mancuso, Brian Abbey   +18 more
wiley   +1 more source

TGF-β1-mediated downregulation of L1CAM in pancreatic ductal adenocarcinoma drives upregulation of collagen 17A1 and MMP2, facilitating tumor invasiveness and metastasis

Cell Death and Disease
The highly fibrotic microenvironment of pancreatic ductal adenocarcinoma (PDAC) poses significant challenges for effective treatment, particularly in drug delivery and tumor progression.
Donatella Delle Cave, Annalisa Di Domenico, Marco Fantuz, Marianna Ciotola, Maria Mangini, Silvia Buonaiuto, Brunella Corrado, Marco Corona, Federica Saracino, Gennaro Andolfi, Ilaria Di Biase, Antonio Cucciardi, Alessandro Carrer, Bruno Sainz, Teresa Pirozzi, Daniele Lo Re, Vincenza Colonna, Gabriella Minchiotti, Anna Chiara De Luca, Enza Lonardo   +19 more
doaj   +1 more source

Different Process, Same Outcome? The Problems of Within‐Party Sortition

The Political Quarterly, EarlyView.
Abstract A recent article in Political Quarterly argues for a ‘sortition of candidature’. We show that because political parties are not themselves socially representative, such a scheme would not result in a socially representative Parliament. Drawing on data from the Party Members Project, we show that while some demographic groups would be better ...
Philip Cowley, Paul Webb, Tim Bale
wiley   +1 more source

El evergetismo como mecanismo de legitimación del poder en la dinastía de los Antoninos

Revista de Historia, 2015
Todo gobierno requiere no solamente legalidad para presidir, sino también legitimidad; es por ello que toda autoridad pone en juego un complejo mecanismo de estrategias encargadas de mantenerla al frente del régimen.
Laura I. Zaccaria
doaj  

Fios da trama poética de Adriano Espínola

Texto Poético, 2016
Este ensaio pretende, na primeira parte, proceder a uma apresentação crítica da obra em progresso do poeta Adriano Espínola, inclusive levando em consideração a discussão atual sobre os caminhos da poesia brasileira contemporânea.
Antônio Donizeti PIRES
doaj   +1 more source

Different Process, Different Outcomes: A Response to Cowley, Webb and Bale

The Political Quarterly, EarlyView.
Abstract This paper responds to Cowley, Webb and Bale's critique of our paper on sortition, parties and political careers. Cowley et al. argue that within‐party sortition will not increase parliamentary descriptive representation (PDR). We largely agree with that claim, which was not the focus of our original paper.
Keith Dowding, William Bosworth, Adriano Guiliani   +2 more
wiley   +1 more source

Pharmacogenomics of Drug Response in Type 2 Diabetes: Toward the Definition of Tailored Therapies?

PPAR Research, 2015
Type 2 diabetes is one of the major causes of mortality with rapidly increasing prevalence. Pharmacological treatment is the first recommended approach after failure in lifestyle changes.
Carla Pollastro, Carmela Ziviello, Valerio Costa, Alfredo Ciccodicola   +3 more
doaj   +1 more source

AI‐Assisted Morphometric Analysis and Molecular Phylogeny for a Dactylogyrid (Monopisthocotyla) Skin Parasite of an Ornamental Crenuchid Fish From Brazil

Acta Zoologica, EarlyView.
ABSTRACT This study presents a formal description and taxonomic appraisal of Cacatuocotyle adrianoi sp. n., a Neotropical parasite belonging to the family Dactylogyridae, integrating AI‐assisted morphometric analyses, molecular data, and phylogenetic reconstruction. Phylogenetic analyses recovered Cacatuocotyle adrianoi sp. n.
J. C. C. Aguiar, M. M. Osaki‐Pereira, N. G. Silva, P. D. Mathews, R. J. Silva   +4 more
wiley   +1 more source

Palaeoenvironmental and climatic changes from the lateglacial of the Saalian to the Late Weichselian in central Poland: a multiproxy study from Józefów

Boreas, EarlyView.
Józefów site is a case study which provides a detailed record of environmental and climate changes and confirms the main traces of the landscape morphogenesis of the Late Pleistocene established in central‐eastern Europe. This study presents a multiproxy reconstruction of palaeoenvironment under variable climatic conditions from the retreat of the ...
Aleksandra Majecka, Jacek Forysiak, Ryszard Borówka, Andreas Börner, Łukasz Bujak, Leszek Marks, Radosław Mieszkowski, Piotr Moska, Daniel Okupny, Małgorzata Pisarska‐Jamroży, Renata Stachowicz‐Rybka, Krzysztof Stachowicz   +11 more
wiley   +1 more source