Results 231 to 240 of about 5,437 (266)

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Adult-Onset Still's Disease Presenting as Aseptic Meningitis: A Case Report and Literature Review. [PDF]

Cureus
Bakhsh R, Dairi K, Alabdali MH, Almehmadi K, Alhindi O, Alhassani R, Alkaabi H, Alsharif A.   +7 more
europepmc   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

Targeting neutrophil-driven inflammation in adult-onset still's disease: molecular insights from gene expression profiles. [PDF]

Arthritis Res Ther
Baek IW, Kim HA, Park KS, Kim KJ.
europepmc   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Challenging diagnosis of adult-onset still's disease (AOSD) in a young male: a case report highlighting the importance of early recognition and management. [PDF]

Ann Med Surg (Lond)
Chowdhury SI, Taj FY, Esha SN, Mifty SK, Khalil I.   +4 more
europepmc   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Increased serum caspase-1 in adult-onset Still's disease. [PDF]

PLoS One
Matsumoto H, Yoshida S, Koga T, Fujita Y, Sumichika Y, Saito K, Temmoku J, Asano T, Sato S, Mizokami M, Sugiyama M, Migita K.   +11 more
europepmc   +1 more source

A Case of Adult-Onset Still's Disease With Hypocomplementemia. [PDF]

Cureus
Kurosawa Y, Takamura S, Wakamatsu A, Kobayashi D, Narita I.   +4 more
europepmc   +1 more source

Pulmonary Arterial Hypertension in Adult-Onset Still's Disease: A Rare but Severe Complication. [PDF]

Am J Case Rep
Quintero G, Mourad S, Kovacs T, Iyyani MK, Al Salihi MO, Qazi O, Carlan SJ.   +6 more
europepmc   +1 more source