Results 81 to 90 of about 103,363 (247)

Adult-onset Still's disease with atypical cutaneous manifestations

Medicine, 2017
The diagnosis of adult-onset Still's disease (AOSD) can be very difficult. There are no specific tests available, and diagnosis is usually based on a symptom complex and the well-described typical evanescent rash seen in the majority of patients. However,
F. J. Narváez Garcia, M. Pascual, Mercè López de Recalde, P. Juárez, I. Morales-Ivorra, J. Notario, A. Jucglà, J. Nolla   +7 more
semanticscholar   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Cryoglobulinemia vasculitis associated with adult‐onset Still's disease

Clinical Case Reports
Key Clinical Message The present case indicates that cryoglobulinemia vasculitis should be considered in the differential diagnosis of purpura in patients with adult‐onset Still's disease (AOSD).
Noriharu Nakagawa, Ai Fujii, Yoshimichi Ueda, Masahide Yamazaki   +3 more
doaj   +1 more source

Adult Onset Still’s Disease: A Case Report with a Rare Clinical Manifestation and Pathophysiological Correlations

Case Reports in Medicine, 2013
Adult-onset Still’s disease is an inflammatory multisystemic disease of unknown etiology. Pleuritis is the most common pulmonary manifestation and pleural effusions are usually exudates with a predominance of neutrophils.
Katerina M. Antoniou, George A. Margaritopoulos, Ioannis Giannarakis, Christianna Choulaki, Nikos Fountoulakis, Nikos M. Siafakas, Prodromos Sidiropoulos   +6 more
doaj   +1 more source

Difficulties in diagnosis and treatment of adult-onset Still's disease concurrent with pericardial effusion as a leading clinical manifestation

Современная ревматология, 2016
The paper considers a case of adult-onset Still's disease that occurred as acute pericarditis, two-spike hectic fever, and neutrophilic leukocytosis in a young man.
V. Yu. Myachikova, A. L. Maslyansky, I. Z. Gaydukova, A. N. Novikova, D. V. Karpova, E. V. Shlyakhto   +5 more
doaj   +1 more source

Adult-onset Still's disease in focus: Clinical manifestations, diagnosis, treatment, and unmet needs in the era of targeted therapies.

Seminars in Arthritis & Rheumatism, 2021
P. Efthimiou, A. Kontzias, Peter Hur, K. Rodha, G. Ramakrishna, P. Nakasato   +5 more
semanticscholar   +1 more source

Adult-onset Still’s disease biological treatment strategy may depend on the phenotypic dichotomy

Arthritis Research & Therapy, 2019
ObjectivesAdult-onset Still’s disease (AOSD) phenotype appears to be dichotomized in systemic or chronic articular forms. As biologicals and particularly interleukin (IL)-1 and IL-6 blockers play a more and more prominent role in the treatment, their ...
F. Vercruysse, T. Barnetche, E. Lazaro, E. Shipley, F. Lifermann, A. Balageas, X. Delbrel, B. Fautrel, C. Richez, T. Schaeverbeke, M. Truchetet   +10 more
semanticscholar   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

The cause of fever and pulmonary infiltrate: a difficult etiological diagnosis

Emergency Care Journal, 2017
Adult-onset Still’s disease is a rare condition that typically presents itself with intermittent fever, arthralgia and salmon colored rash. The involvement of the in lung is less common and very rare.
Bahjat Barakat, Raffaele Pezzilli
doaj   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source