Results 81 to 90 of about 5,437 (266)

Hemophagocytic syndrome, a rare variant of Still’s disease [PDF]

, 2017
Adult onset still’s disease is a rare systemic inflammatory disorder of unknown etiology that is responsible for a significant number of cases of fever of unknown origin (FUO) and musculoskeletal diseases.
Bhave, Neha, Gupta, Dinesh, Kashyap, Prashant   +2 more
core   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The progression of initial symptoms and its relationship with the clinical course in adult-onset Still’s disease: from the KEIO-AOSD cohort

EULAR Rheumatology Open
: Objectives: Adult-onset Still’s disease presents with nonspecific and heterogeneous features. This study aims to elucidate the development of initial symptoms and their relationship with the disease course in adult-onset Still’s disease.
Hiroya Tamai, Jun Kikuchi, Tsutomu Takeuchi, Yuko Kaneko   +3 more
doaj   +1 more source

Macrophage Activation Syndrome Associated with Adult-Onset Still’s Disease Successfully Treated with Anakinra

Case Reports in Rheumatology, 2016
Macrophage activation syndrome (MAS) is a potentially fatal complication of Adult-Onset Still’s disease (Still’s disease). Whereas an increasing body of evidence supports interleukin-1 (IL-1) blockade as a promising treatment for Still’s disease, whether
Aswini Kumar, Hiroshi Kato
doaj   +1 more source

Interleukin-18 as a diagnostic marker of adult-onset Still’s disease in older patients: a case report and review of the literature

Journal of Medical Case Reports, 2018
Background Adult onset Still’s disease is a systemic auto-inflammatory condition of unknown etiology characterized by intermittent spiking high fever, an evanescent salmon-pink or erythematous maculopapular skin rash, arthralgia or arthritis, and ...
Daisuke Usuda, Yoshiki Furumura, Kento Takeshima, Ryusho Sangen, Yasuhiro Kawai, Yuji Kasamaki, Yoshitsugu Iinuma, Tsugiyasu Kanda   +7 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Sequencing of blaIMP-Carrying IncN2 Plasmids, and Comparative Genomics of IncN2 Plasmids Harboring Class 1 Integrons [PDF]

, 2017
This work presents the complete nucleotide sequences of p0801-IMP from Klebsiella pneumoniae, p7121-IMP from K. oxytoca, and p17285-IMP from Citrobacter freundii, which are recovered from three different cases of nosocomial infection.
Defu Zhang, Dongsheng Zhou, Haihong Fang, Jiao Feng, Jinglin Wang, Qiang Sun, Shuiping Chen, Weijun Chen, Xiaoyuan Jiang, Xiuyun Yin, Yajun Song, Yigang Tong, Yuanhong Xu, Zhe Yin   +13 more
core   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

ADULT-ONSET STILL'S DISEASE: DIAGNOSIS AND TREATMENT

Современная ревматология, 2009
The paper describes adult-onset Still's disease (AOSD), a rare multisystemic disease of unknown etiology that is referred to as seronegative rheumatoid arthritis.
Rimma Mikhailovna Balabanova, O N Egorova   +1 more
doaj   +3 more sources

RNA recognition by human TLR8 can lead to autoimmune inflammation. [PDF]

, 2013
Studies on the role of the RNA receptor TLR8 in inflammation have been limited by its different function in human versus rodents. We have generated multiple lines of transgenic mice expressing different levels of human TLR8. The high copy number chimeras
Ablasser, Alma-Martina Cepika, Barbalat, Barrat, Berry, Campbell, Cassidy, Chad Crain, Christensen, Claudio Tripodo, Cristiana Guiducci, Deane, Demaria, Döring, Ewald, Finkelberg, Forsbach, Franck J. Barrat, Fukui, Ganguly, Gantier, Gorden, Guiducci, Guiducci, Hattermann, Heil, Hemmi, Janke, John J. Cush, Lan, Liu, Lynda Bennett, Maschalidi, Mei Gong, Mellins, Mouchess, Nickerson, Pascual, Pierre Quartier, Pisitkun, Prinz, Quartier, Robert L. Coffman, Sacre, Sarvestani, Sparwasser, Subramanian, Virginia Pascual, Vollmer, Walsh, Wang, Zandieh, Zhaohui Xu   +52 more
core   +2 more sources