Results 191 to 200 of about 5,197,820 (319)

Whole-organ single-cell mapping defines growth dynamics and clonal organization in developing and adult zebrafish livers. [PDF]

PLoS Biol
Roan HY, Tian X, Chu WC, Lee CM, Chen H, Santoso F, Wang CH, Liu YH, Kumar U, Hsiao HY, Yuh CH, Chen BC, Chen CH.   +12 more
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

The mediating role of personality functioning impairment between childhood maltreatment and adult mental health problems. [PDF]

Eur J Psychotraumatol
d'Huart D, Frey S, Mazreku G, Hauri I, Bentz D, Birkhölzer M.   +5 more
europepmc   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Prophylactic Proton Pump Inhibitors in Critically Ill Patients Undergoing Invasive Ventilation: A Systematic Review and Meta-Analysis of Randomized Trials

Critical Care Research and Practice
Jinlu Hu, Haiyan Ye, Bo Li, Xuemei Zheng
doaj   +1 more source

'I Do Not Want to Depend Too Much on My Children': Motivations and Challenges for Intergenerational Co-Residence Among Older Adults in Indonesia. [PDF]

J Cross Cult Gerontol
Hanum L, Newcombe P, Nurwianti F, Scott T.   +3 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bioaccumulation dynamics of perfluorooctane sulfonic acid (PFOS) and a binary mixture of PFOS and perfluorohexane sulfonic acid (PFHxS) in northern bobwhite (Colinus virginianus): a mini review. [PDF]

Ecotoxicology
Kikanme KN, Karnjanapiboonwong A, Dennis NM, Angappan R, Isukuru EJ, Salice CJ, Anderson TA.   +6 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source