Results 201 to 210 of about 3,601,991 (269)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Content validity, face validity and comprehensiveness of generic quality-of-life measures in adults and children with rare genetic conditions and their carers: a think aloud qualitative study. [PDF]

Qual Life Res
Bourke M, Zhu X, Boughtwood T, Gaff C, Hunter A, Mulhern B, Peasgood T, Stuart C, Buchanan J, Goranitis I.   +9 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

XLH Matters 2024 GCC Edition: Insights and Recommendations to Improve Outcomes for People Living With XLH in the Gulf Region. [PDF]

Clin Med Insights Endocrinol Diabetes
Seefried L, Al Badi M, Frookh H, Al-Sagheir A, Fiad TM, Deeb A, Al Sumaily A, Attia N, Habeb A, Alzahrani A, Mughal MZ.   +10 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Management of Asymptomatic Breast Implant Rupture in Older Adult Patients: A Scoping Review, Discussion, and Recommendations. [PDF]

Plast Reconstr Surg Glob Open
Vernice NA, Boyd CJ, Hemal K, Amro C, Sorenson TJ, Park J, Karp NS, Cohen O, Choi M.   +8 more
europepmc   +1 more source

The causal relationships and potential pathways between birth weight and cardiovascular diseases: A human genomics study. [PDF]

Medicine (Baltimore)
Li X, Cao Y, Cai J, Yu C, Li L, Ge Q, Liu Z, Xiao C.   +7 more
europepmc   +1 more source

Pediatric versus adult self-inflating bags for cardiopulmonary resuscitation of adult patients with cardiac arrest - a non-randomized controlled trial. [PDF]

Resusc Plus
Kowsthubha BG, Manu Ayyan S, Anandhi D, Vivekanandan Pillai M.   +3 more
europepmc   +1 more source

Education Research: The Future of Child Neurology Residency Training: The Perspective of a Child Neurology Society Task Force. [PDF]

Neurol Educ
Cohen BH, Gilbert DL, Xixis K, Banwell BL, Singh A, Pagano LM, Brooks-Kayal A, Kirkpatrick L, Schor NF, Mar SS, Crowder D, Terrell M, Kang PB.   +12 more
europepmc   +1 more source