Results 71 to 80 of about 8,262,084 (314)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Identification Of Mitotically Competent SOX2+ Cells In White Matter Of Normal Human Adult Brain [PDF]

, 2011
SOX2 expression is linked to the undifferentiated state of stem cells in mammalian neurogenic niches. While its expression has been reported in the adult human subventricular zone (SVZ), to date it has not been detected in adult human white matter.
Angel Ayuso-Sacido, Antonio Gutierrez-Martin, Carmen Escobedo-Lucea, Jorge Oliver-De la Cruz, Jose Manuel Garcia-Verdugo, Josefa Carrion-Navarro   +5 more
core   +1 more source

The Contemporary Porn Debate - Perceptions of Sexual Health of Porn Actors, The 2013 HIV crisis, and Recognizing the Complexities of the Porn Industry [PDF]

, 2020
Between August 2012 and January 2013, four adult film performers based in California tested positive for HIV which triggered a moratorium on production, and led the state of California to mandate condom usage in the industry under the Safer Sex in the ...
Gooya, Nasreen C.
core   +1 more source

The effects of adult guidance and peer discussion on the development of children's representations: evidence from the training of pedestrian skills [PDF]

, 2005
It was hypothesised that practical training is effective in improving children's pedestrian skills because adult scaffolding and peer discussion during training specifically promote E3 level representation (linguistically-encoded, experientially-grounded,
Foot, Hugh, McLaren, Brian, Morrison, Sheila, Thomson, James, Tolmie, Andrew, Whelan, Kirstie   +5 more
core   +3 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The experience and rehabilitation of patients operated on external genital endometriosis

Кубанский научный медицинский вестник, 2016
During present research, 216 patients with external genital endometriosis were examined. Examined women had been suffering from complaints (pelvic pain, dyspareunia, psycho-emotional disorders) from 1.5 to 19 years.
V. A. Krutova, T. G. Melkoniants, N. A. Kravtsova, E. G. Pirozhnik, L. V. Makarenko, A. V. Ephimenko, I. I. Kravtsov, A. A. Ordokova, A. N. Titova   +8 more
doaj  

Efficacy and Safety of CART Cell Therapy in Aggressive B‐Cell Lymphomas Involving the Gastrointestinal Tract

Cancer Reports
Objective Currently, chimeric antigen receptor T‐cell (CART) therapy represents a highly effective approach for relapsed/refractory B‐cell lymphomas. However, it also carries treatment‐related risks.
Lixia Ma, Yimeng Dou, Rui Liu, Teng Xu, Fan Yang, Peihao Zheng, Shaomei Feng, Yuelu Guo, Hui Shi, Fei Xue, Biping Deng, Xiaoyan Ke, Kai Hu   +12 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source