Results 101 to 110 of about 1,711,468 (301)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Information About Adult ADHD

open access: yes, 2017
This introductory chapter provides psychoeducation about ADHD and how it manifests in adults. The symptoms of ADHD are described. The cognitive-behavioral model of adult ADHD is presented. The chapter explains why adults sometimes need additional therapy,
Michael W. Otto   +3 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Assessment and monitoring of treatment response in adult ADHD patients: current perspectives

open access: yes, 2017
J Russell Ramsay Adult ADHD Treatment & Research Program, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA, USA Abstract: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental syndrome that emerges in ...
Ramsay JR
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Treatment in adult ADHD

open access: yes, 2018
The treatment of ADHD in adults is very similar to that recommended for children and adolescents. There have been many more clinical trials evaluating the efficacy and safety of the drugs used in ADHD treatment on children than adults.
Philip Asherson   +1 more
core   +1 more source

Co-morbidity and patterns of care in stimulant-treated children with ADHD in the Netherlands [PDF]

open access: yes, 2009
This study aimed at investigating the use of psychosocial interventions and psychotropic co-medication among stimulant-treated children with attention-deficit hyperactivity disorder (ADHD) in relation to the presence of psychiatric co-morbidity ...
Hugtenburg, J.G.   +18 more
core   +1 more source

Prevalence of attention deficit hyperactivity disorder and its relation with depression

open access: yesمجله دانشگاه علوم پزشکی گرگان, 2014
Background and Objective: According to destructive consequences of untreated attention deficit hyperactivity disorder (ADHD), this study was done to evaluate of the prevalence of adult ADHD and its relation with depression among Iranian students. Methods:
Parvaresh N   +3 more
doaj  

An online survey of Turkish psychiatrists’ attitudes and experiences regarding adult attention deficit hyperactivity disorder in clinical practice

open access: yesPsychiatry and Clinical Psychopharmacology, 2021
Objective: Adult attention deficit hyperactivity disorder (ADHD) can be an extremely debilitating neurodevelopmental disorder that often persists beyond childhood, affecting 2.5-5% of adults in the general population.
Bengi Semerci, Gamze Ergil Altin
doaj  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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