Results 111 to 120 of about 1,616,423 (295)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

An online survey of Turkish psychiatrists’ attitudes about and experiences of adult attention deficit hyperactivity disorder in clinical practice

Neuropsychiatric Disease and Treatment, 2016
Murat Altın,1 Gamze Ergil Altın,2 Bengi Semerci3 1Department of Psychiatry, Medical Park Gaziosmanpasa Hospital, 2Department of Psychiatry, Boylam Psychiatry Institute, 3Department of Psychiatry, Bengi Semerci Institute, Istanbul, Turkey Objective ...
Altın M, Altın GE, Semerci B
doaj  

Prevalence of Adult Attention-Deficit Hyperactivity Disorder in Patients with Substance Use Disorder: A Cross-sectional Study

Annals of Indian Psychiatry
Background: Adult attention-deficit hyperactivity disorder (ADHD) is frequently underdiagnosed, especially among individuals with substance use disorders (SUDs).
Ashwini Mule, Vivek Chincholkar, Alkesh Patil, Neha Patel, Vishal Indla, Indla Ramasubba Reddy   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Prevalence of Adult Attention Deficit Hyperactivity Disorder (Adult ADHD): Tabriz.

Iranian Journal of Psychiatry, 2014
Objective: Attention deficit hyperactivity disorder in adults (adult ADHD) is gaining more attention nowadays. Nevertheless, very few studies have addressed this issue in Iran.
Shahrokh Amiri, Mohammad Ali Ghoreishizadeh, Homayoun Sadeghi-Bazargani, Mohammad Jonggoo, Javad Golmirzaei, Salman Abdi, Salman Safikhanlo, Abolfazl Asadollahi   +7 more
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The prevalence of undiagnosed attention-deficit/hyperactivity disorder among undergraduate medical students: a survey from Pakistan

BMC Psychiatry
Background Attention-deficit/hyperactivity disorder (ADHD) is now acknowledged as a significant public health concern, a persistent neurodevelopmental disorder.
Hafsa Sabir, Misha Khan, Komal Imran, Zaib-Un Nisa, Samar A. Amer   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Gender Differences in Symptom Presentations of ASRS-Based Probable Adult ADHD Among Patients Receiving Treatment for Substance Use Disorders in Nairobi, Kenya

Eastern African Journal of Humanities and Social Sciences
Adult Attention-Deficit/Hyperactivity Disorder (ADHD) commonly co-occurs with Substance Use Disorders (SUDs), yet evidence regarding gender differences in ADHD symptom presentations among treatment-seeking populations in Sub-Saharan Africa remains ...
Lucy Wanjiku Murage, Stella Nyagwencha, Michael Kihara   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source