Results 91 to 100 of about 573,264 (305)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Attachment networks in young adults

Frontiers in Psychology
IntroductionThis study investigated attachment networks in a sample of Italian young adults. Attachment networks were defined in terms of attachment functions, attachment strength, the presence of a primary figure, and full-blown attachments.MethodParticipants were 405 young adults, and we studied the effects of the demographic variables of gender ...
Carli L. L., Alì P. A., Anzelmo E., Caprin C., Crippa F., Gallucci M., Moioli L., Traficante D., Feeney J. A.   +8 more
openaire   +3 more sources

The Effect of Childhood Emotional Maltreatment on Romantic Relationships in Young Adulthood: A Double Mediation Model Involving Self-Criticism and Attachment [PDF]

, 2016
Objective: Despite growing recognition of the importance of childhood emotional maltreatment (CEM) on the development of psychopathology, very few studies have addressed its impact on adult romantic relationship functioning, particularly among otherwise ...
Cohen, G, Lassri, D, Luyten, P, Shahar, G   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Holding back the tears: Individual differences in adult crying proneness reflect attachment orientation and attitudes to crying [PDF]

, 2016
Despite being a universal human attachment behavior, little is known about individual differences in crying. To facilitate such examination we first recommend shortened versions of the attitudes and proneness sections of the Adult Crying Inventory using ...
Ainsworth, Akaike, Baldwin, Bartholomew, Bindra, Bollen, Bowlby, Brennan, Brown, Brown, Byrne, Cassidy, Cassidy, Cheung, Collins, Cornelius, Denckla, Feeney, Feeney, Festinger, Fraley, Fraley, Frey, Gillath, Hastrup, Hayes, Hendriks, Hu, Kottler, Laan, Lockwood, Meyer, Mikulincer, Mikulincer, Montague, Nelson, Paulhus, Rowe, Scheirs, Shaver, Simpson, Spokas, Strathearn, Ullman, Vingerhoets, Vingerhoets, Vingerhoets, Vingerhoets, Vingerhoets, Wei, Wei, Westland, Wong, Zeifman   +53 more
core   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Attachment style and family presence preference during invasive nursing procedures

Journal of Health Sciences, 2018
Introduction: The attachment style and family presence preference are important during invasive medical procedures. We aimed to analyze the effects of adult attachment styles of the patients which prefer the presence of their family members during the ...
Nurten Kaya, Nuray Turan
doaj   +1 more source

Attachment styles of dermatological patients in europe : A multicentre study in 13 countries [PDF]

, 2017
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License https://creativecommons.org/licenses/by-nc/4.0/. © 2017 Acta Dermato-Venereologica.Attachment styles of dermatological
Altmayer, Anita, Altunay, Ilknur K., Balieva, Flora, Dalgard, Florence, Finlay, Andrew Y., Gieler, Uwe, Halvorsen, Jon Anders, Jemec, Gregor B.E., Kupfer, Jörg, Lien, Lars, Linder, Dennis, Marron, Servando E., Misery, Laurent, Poot, Francoise, Romanov, Dmitry, Salek, Sam S., Sampogna, Francesca, Szabó, Csanád, Szepietowski, Jacek C., Tomas-Aragones, Lucia, Van Middendorp, Henriët   +20 more
core   +12 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source