Results 61 to 70 of about 182,974 (255)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Attachment networks in young adults

Frontiers in Psychology
IntroductionThis study investigated attachment networks in a sample of Italian young adults. Attachment networks were defined in terms of attachment functions, attachment strength, the presence of a primary figure, and full-blown attachments.MethodParticipants were 405 young adults, and we studied the effects of the demographic variables of gender ...
Carli L. L., Alì P. A., Anzelmo E., Caprin C., Crippa F., Gallucci M., Moioli L., Traficante D., Feeney J. A.   +8 more
openaire   +5 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Attachment style and family presence preference during invasive nursing procedures

Journal of Health Sciences, 2018
Introduction: The attachment style and family presence preference are important during invasive medical procedures. We aimed to analyze the effects of adult attachment styles of the patients which prefer the presence of their family members during the ...
Nurten Kaya, Nuray Turan
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The Influence of Attachment Styles and Personality Organization on Emotional Functioning After Childhood Trauma

Frontiers in Psychiatry, 2019
Background: Current literature suggests a tenuous link among childhood trauma, personality organization, adult attachment, and emotional functioning in various psychiatric disorders.
Jürgen Fuchshuber, Jürgen Fuchshuber, Michaela Hiebler-Ragger, Michaela Hiebler-Ragger, Adelheid Kresse, Hans-Peter Kapfhammer, Human Friedrich Unterrainer, Human Friedrich Unterrainer, Human Friedrich Unterrainer   +8 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Coping, attachment style and resilience: the mediating role of alexithymia

Mediterranean Journal of Clinical Psychology, 2018
Literature show that the presence of an insecure attachment is at the root of a difficulty in affect regulation and of the implementation of dysfunctional coping and resilience strategies.
Giuseppe Craparo, Paola Magnano, Maria Valentina Zapparrata, Alessio Gori, Giulia Costanzo, Ugo Pace, Monica Pellerone   +6 more
doaj   +1 more source