Results 131 to 140 of about 2,726,109 (350)
Effect of a randomized group intervention for depression among Nigerian pre-service adult education teachers. [PDF]
Medicine (Baltimore), 2023 Okeke NM +9 more
europepmc +1 more source
From Silos to Seamlessness: Towards a Cross-sectoral Funding Model for Post-compulsory Education and Training [PDF]
educational finance, postcompulsory education, vocational education, higher education, adult education, recurrent ...
Bruce Chapman +2 more
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
The promotion of active aging through older adult education in the context of population aging. [PDF]
Front Public Health, 2022 Zhang K +8 more
europepmc +1 more source
‘Workers’ Educational Association: A Crisis of Identity? Personal Perspectives on Changing Professional Identities. [PDF]
, 2008 This work is concerned with how the State’s general educational policy affects the structure, identity and practices of the informal adult education sector. The poster focuses on the Workers’ Educational Association, a voluntary movement established over
Davis, SJ
core
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Reimagining adult education and lifelong learning for all: Historical and critical perspectives. [PDF]
Int Rev Educ, 2022 Benavot A +3 more
europepmc +1 more source