Results 281 to 290 of about 110,453 (370)

Ginsenoside Rg1 as a Multifunctional Therapeutic Agent: Pharmacological Properties, Molecular Mechanisms and Clinical Perspectives in Complementary Medicine

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Ginsenoside Rg1 (Rg1) from Panax ginseng shows multifunctional health effects. Although oral bioavailability is low and blood–brain barrier (BBB) penetration is limited, delivery systems such as liposomes and nanoparticles may improve exposure. Rg1 reduces inflammation/oxidative stress by inhibiting nuclear factor‐κB (NF‐κB) signaling and reactive ...
Hernán Cortés, Enrique Lima, Lorena Duarte‐Peña, Sheila I. Peña‐Corona, Zainab M. Almarhoon, Rajesh Kaverikana, Shivaprasad Shetty Mangalpady, Vinayaka Babu Shet, Nikshitha Manjeshwar, Javad Sharifi‐Rad, Jen‐Tsung Chen, Gerardo Leyva‐Gómez, William N. Setzer, Daniela Calina   +13 more
wiley   +1 more source

MeCP2 Modulates Depression-Like Behaviors Comorbid to Chronic Pain by Regulating Adult Hippocampal Neurogenesis. [PDF]

CNS Neurosci Ther
Sun Y, Zhang Y, Chen Y, Peng H, Cheng T, Sun X, Liu JG, Xu C.   +7 more
europepmc   +1 more source

Maternal immune activation primes deficiencies in adult hippocampal neurogenesis

, 2021
Amalie C. M. Couch, Thomas Berger, Bjørn Hanger, Rugilė Matulevičiūtė, Deepak P. Srivastava, Sandrine Thuret, Anthony C. Vernon   +6 more
openalex   +1 more source

Prolactin Receptor Deficiency Promotes Hypomyelination in White Matter Tracts During Postnatal Central Nervous System Maturation in Mice

Glia, Volume 74, Issue 2, February 2026.
Prolactin action is essential for proper myelination of white matter tracts during neonatal and prepubertal stages in mice. Lack of prolactin receptor (Prlr−/−) signaling leads to hypomyelination and impaired locomotor function. ABSTRACT A large wave of myelination in the central nervous system (CNS) of mammals occurs during postnatal development ...
Ana L. Ocampo‐Ruiz, José L. Dena‐Beltrán, Marco A. Dimas‐Rufino, Ximena Castillo, Dina I. Vazquez‐Carrillo, Andrea Silos‐Guajardo, Xarubet Ruiz‐Herrera, Edith Garay, Gonzalo Martínez de la Escalera, Carmen Clapp, Rogelio O. Arellano, Abraham J. Cisneros‐Mejorado, Yazmín Macotela   +12 more
wiley   +1 more source

Magnesium-L-threonate Ameliorates Cognitive Deficit by Attenuating Adult Hippocampal Neurogenesis Impairment in a Mouse Model of Alzheimer's Disease. [PDF]

Exp Neurobiol
Xiong Y, Yang Y, Ruan Y, Ou W, Hu Z, Li W, Xiao N, Liao W, Liu J, Liu Z, Luo Q, Liu F, Liu J.   +12 more
europepmc   +1 more source

Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion

Glia, Volume 74, Issue 2, February 2026.
Loss of astrocytic MCT1 does not cause late onset neurodegeneration. As ubiquitous MCT1 deletion causes axonal degeneration, oligodendrocytes and potentially other cells are more prominent drivers of MCT1‐mediated metabolic support of neurons. ABSTRACT We recently reported that the loss of oligodendrocyte metabolic support through the lactate and ...
Thomas Philips, Emily G. Thompson, Olivia Spead, Balaji G. Vijayakumar, Erica R. Kent, Sean J. Miller, Treasure Nwokeleme, Svetlana Vidensky, Mohamed Hassan Farah, Jeffrey D. Rothstein   +9 more
wiley   +1 more source

Adolescent Vitamin D Supplementation Reverses Neuroplasticity and Motivational Deficits Induced by Developmental Alcohol Exposure and Early‐Life Stress

International Journal of Developmental Neuroscience, Volume 86, Issue 1, February 2026.
Adolescent vitamin D supplementation reverses behavioural and neuroplastic impairments induced by early‐life alcohol exposure and maternal separation in rats. Postnatal ethanol exposure (PND 4–10) and maternal separation stress (PND 2–14) led to motivational deficits and altered hippocampal plasticity.
Anelise Pereira Alves, Claudia Daniele Bianco, Clarice Mariano Fernandes, Ian Carlos Hübner, Patricia S. Brocardo   +4 more
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Spatial transcriptomic analysis of adult hippocampal neurogenesis in the human brain. [PDF]

J Psychiatry Neurosci
Simard S, Rahimian R, Davoli MA, Théberge S, Matosin N, Turecki G, Nagy C, Mechawar N.   +7 more
europepmc   +1 more source

Design of Experiments (DoE)‐Optimized Polymeric Oxytocin Nanoparticles for Enhanced Nose‐to‐Brain Delivery

Small, Volume 22, Issue 8, 6 February 2026.
Intranasal (IN) delivery of PEGylated PLGA nanoparticles (NPs) loaded with oxytocin (OT) (OT‐NP‐PEG) is investigated as a strategy to enhance OT transport to the brain for treating autism and other neuropsychiatric disorders. The optimized NP formulation demonstrates appropriate physicochemical characteristics, improved stability, and enhanced mucosal ...
Naveed Ahmad, Shunping Han, Rifka Utami, Rafal Baker, Dina Helal, Zhuoni Li, Mark Tricklebank, Yannis Paloyelis, Julie Wang, Marija M. Petrinovic, Sukhi Bansal, Khuloud T. Al‐Jamal   +11 more
wiley   +1 more source