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Unraveling human adult hippocampal neurogenesis [PDF]
Nature Protocols, 2020 Adult neurogenesis occurs in a few selected regions of the mammalian brain. One such region is the hippocampus, the so-called gateway to memory, where adult hippocampal neurogenesis (AHN) occurs. Here, we provide a comprehensive description of the methods used in our laboratory to unambiguously detect a population of immature neurons in the human ...
M. Flor-García +5 more
semanticscholar +4 more sources
Wnt signalling regulates adult hippocampal neurogenesis
Nature, 2005 The generation of new neurons from neural stem cells is restricted to two regions of the adult mammalian central nervous system: the subventricular zone of the lateral ventricle, and the subgranular zone of the hippocampal dentate gyrus. In both regions, signals provided by the microenvironment regulate the maintenance, proliferation and neuronal fate ...
D. Lie +10 more
semanticscholar +7 more sources
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Vascular niche for adult hippocampal neurogenesis
The Journal of Comparative Neurology, 2000The thin lamina between the hippocampal hilus and granule cell layer, or subgranule zone (SGZ), is an area of active proliferation within the adult hippocampus known to generate new neurons throughout adult life. Although the neuronal fate of many dividing cells is well documented, little information is available about the phenotypes of cells in S ...
T. Palmer, Andrew R. Willhoite, F. Gage
semanticscholar +3 more sources
Adult hippocampal neurogenesis and antidepressants effects.
Current Opinion in Pharmacology, 2020The hippocampus is particularly involved in cognitive processes and is a key regulator of stress responses and emotions. Therefore, the role of adult-born neurons in this region has become a crucial field of research in order to understand mood and stress disorders, such as major depression.
Barbara Planchez, A. Surget, C. Belzung
semanticscholar +3 more sources
Phytomedicine, 2022
BACKGROUND Depression is a common mental disorder characterized by persistent sadness and lack of interest or pleasure in previously rewarding or enjoyable activities. Understandably, the causes of depression are complex.
Lijin Feng, Hang Xing, Kuo Zhang
semanticscholar +1 more source
BACKGROUND Depression is a common mental disorder characterized by persistent sadness and lack of interest or pleasure in previously rewarding or enjoyable activities. Understandably, the causes of depression are complex.
Lijin Feng, Hang Xing, Kuo Zhang
semanticscholar +1 more source
Adult hippocampal neurogenesis in depression
Nature Neuroscience, 2007The development of new treatments for depression is predicated upon identification of neural substrates and mechanisms that underlie its etiology and pathophysiology. The heterogeneity of depression indicates that its origin may lie in dysfunction of multiple brain regions.
Amar, Sahay, Rene, Hen
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Adult hippocampal neurogenesis and aging
European Archives of Psychiatry and Clinical Neuroscience, 2007The demographic changes in the foreseeable future stress the need for research on successful cognitive aging. Advancing age constitutes a primary risk factor for disease of the central nervous system most notably neurodegenerative disorders. The hippocampus is one of the brain regions that is prominently affected by neurodegeneration and functional ...
Friederike, Klempin, Gerd, Kempermann
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