Results 81 to 90 of about 179,906 (293)
Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1
Advanced Science, EarlyView.Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang +10 more
wiley +1 more source
All‐PEG‐Like Block Copolymers Self‐Assemble into Stealth Nanocarriers for Drug Delivery
Advanced Science, EarlyView.Self‐assembling nanoparticles composed entirely of POEGMA are engineered by exploiting side‐chain–dependent amphiphilicity and tunable thermoresponsive behavior. These single‐material nanocarriers encapsulate diverse hydrophobic drugs with high efficiency, retain therapeutic activity, improve in vivo efficacy, and evade anti‐PEG antibodies.
Parul Sirohi +15 more
wiley +1 more source
Canadian Journal of Infectious Diseases and Medical Microbiology, 2005 INTRODUCTION: During the past decade, a trend toward increasing cases of Bordetella pertussis in older children and adults has been witnessed in Canada.
Kami Kandola +3 more
doaj +1 more source
The Update, March 22, 2010 [PDF]
, 2010 The Update is a bi-weekly web newsletter published by the Iowa Department of Public Health's Bureau of Family Health. It is posted the second and fourth week of every month, and provides useful job resource information for departmental health care ...
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GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Frontiers in Immunology, 2017 Immunization is key to preventing infectious diseases, a leading cause of death early in life. However, due to age-specific immunity, vaccines often demonstrate reduced efficacy in newborns and young infants as compared to adults.
Francesco Borriello +30 more
doaj +1 more source
Advanced Science, EarlyView.We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang +10 more
wiley +1 more source
Should outbreak response immunization be recommended for measles outbreaks in middle- and low-income countries? An update. [PDF]
, 2011 Measles caused mortality in >164,000 children in 2008, with most deaths occurring during outbreaks. Nonetheless, the impact and desirability of conducting measles outbreak response immunization (ORI) in middle- and low-income countries has been ...
Al Wahaibi +60 more
core +2 more sources
Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination
Advanced Science, EarlyView.Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi +21 more
wiley +1 more source
Entertainment Education and Health in the United States [PDF]
, 2004 Discusses the history of "entertainment education" -- the use of entertainment media as a means of educating viewers about health and social issues -- and provides several examples of entertainment education from American ...
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