Results 91 to 100 of about 906,055 (304)

Adult onset cryopyrin-associated periodic syndrome due to germline missense mutation in NLRP3 in a previously healthy middle-aged woman

Frontiers in Immunology
BackgroundCryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory disease caused by a gain-of-function mutation in the NLRP3 gene, which regulates inflammasome-mediated interleukin-1β (IL-1β) production.
Sung Ik Cho, Sheehyun Kim, Ju Yeon Kim, Jeong-Won Kim, Sujin Pyeon, Won-Woo Lee, Won-Woo Lee, Jin Kyun Park   +7 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Etiologies of patients with adult-onset epilepsy over the past 25 years: a retrospective study in China

BMC Neurology
Objective This study aimed to describe the changes in the etiology of adult epilepsy in different age groups over the past 25 years, with consideration of different time periods.
Xu Zhang, Ziyu Wang, Feng Xiang, Yang Li, Xiaobing Shi, Chenjing Shao, Senyang Lang, Xiangqing Wang   +7 more
doaj   +1 more source

Limited diagnostic value of procalcitonin in early diagnosis of adult onset Still’s disease

, 2016
A 17-year-old female patient was referred to the Infectious Diseases Ward because of fever lasting for 14 days. On admission to the hospital the patient was in a generally good state, without any abnormalities on physical examination.
Ewelina Gowin, Jacek Wysocki
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Adult-onset type II citrullinemia: Current insights and therapy

, 2018
Kiyoshi Hayasaka,1,2 Chikahiko Numakura1 1Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan; 2Department of Pediatrics, Miyukikai Hospital, Kaminoyama, Japan Abstract: Citrin deficiency is a recessively inherited metabolic
Hayasaka K, Numakura C
core  

Transition into adult healthcare services in Scotland –findings from a study concerning service users at the Scottish Spina Bifida Association [PDF]

, 2014
Background and Aims Literature on interventions that enable young people with Spina Bifida and/or Hydrocephalus to have smooth transition, into adult healthcare services, stress the need for the process to start early and to include all family members ...
Wynd , Andrew H D, Carachi, Robert, Levy, Sharon; id_orcid, Levy, Sharon, ,   +4 more
core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Adult-onset eosinophilic asthma [PDF]

, 2017
In the last decades, it has been recognized that asthma is not a single disease, but comprises several clinical syndromes, which all share respiratory symptoms and lung function abnormalities, associated with different types of airway inflammation. These
de Groot, Jantina C., de Groot, J.C.
core   +1 more source

Adult onset Leigh syndrome

Annals of Indian Academy of Neurology, 2007
Leigh syndrome is a rare progressive mitochondrial disorder of oxidative metabolism. Though it has been reported in infancy and childhood, it is rarely described in adults.
Pandit Lekha, Narayanappa Gayatri, Shetty Lathika, Krishna Sree   +3 more
doaj