Results 81 to 90 of about 906,055 (304)

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

The ocular motor features of adult-onset alexander disease: a case and review of the literature

, 2011
A 51-year-old Chinese man presented with gaze-evoked nystagmus, impaired smooth pursuit and vestibular ocular reflex cancellation, and saccadic dysmetria, along with a family history suggestive of late-onset autosomal dominant parkinsonism.
Jason J S Barton, Barton, Jason J S, Caroli, Francesco, Vertinsky, A Talia, Gerald Pfeffer, A Talia Vertinsky, Pfeffer, Gerald, Isabella Ceccherini, Abegg, Mathias, Mathias Abegg, Ceccherini, Isabella, Francesco Caroli   +11 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Comparative analysis of the clinical aspects of colorectal cancer in young adult and older adult patients in Saudi Arabia

Frontiers in Oncology
IntroductionRecent studies have shown an increase in the prevalence of early-onset colorectal cancer (CRC) in people aged 20–49 compared to those aged 50–74, with a more rapid increase in the younger age groups.
Marwh G. Aldriwesh, Marwh G. Aldriwesh, Amer R. Aljaian, Amer R. Aljaian, Khalid M. Alorf, Khalid M. Alorf, Mohammed A. Bayounis, Mohammed A. Bayounis, Yazeed H. Alrayani, Yazeed H. Alrayani, Winnie Philip, Winnie Philip, Mohammed Algarni, Mohammed Algarni, Mohammed Algarni, Nahar A. Alselaim, Nahar A. Alselaim, Nahar A. Alselaim, Raniah S. Alotibi, Raniah S. Alotibi   +19 more
doaj   +1 more source

Pathway discovery using transcriptomic profiles in adult-onset severe asthma

, 2017
Background Adult-onset severe asthma is characterized by highly symptomatic disease despite high-intensity asthma treatments. Understanding of the underlying pathways of this heterogeneous disease is needed for the development of targeted treatments ...
Flemming, Louise J, Chung, Kian Fan, Howarth, Peter H., Shaw, Dominique E., Vissing, Nadja, Fleming, Louise J., Shaw, Dominique E, Auffray, C, U-BIOPRED Study Group, Chung, K. F., Sterk Peter, J., Bansal, Aruna T., Auffray, Charles, Pandis, Yannis, Sousa, Ana R., Pavlidis, Stelios, De Meulder, Bertrand, Loza, Matt J, Adcock, Ian M, Wagener, Ariane H., Howarth, Peter, Bansal, Aruna T, Bates, Steve, Sterk, Peter J, U-BIOPRED, Study Group, Fowler, Stephen J, Bisgaard, Hans, Guo, Y., Zwinderman, Koos, Brinkman, Paul, Corfield, Julie, Hekking, Pieter-Paul, Adcock, Ian M., Thorsen, Jonathan, Zetterquist, Wilhelm, Djukanovic, Ratko, Wen, Yu, Bates, Steve A, Bønnelykke, Klaus, Sterk, Peter J., Loza, Matt J., Wagener, Ariane H, Fowler, Stephen; id_orcid, Sousa, Ana R, Fowler, Stephen J., Bates, Steve A., Lefaudeux, Diane, Fleming, Louise J, Howarth, Peter H, Meiser, Andrea, Adcock, Ian M., Guo, Y, Loza, Matthew J, Sun, Kai, Baribaud, Fred, Lutter, Rene, Chung, K.F., Hekking, Pieter-Paul W, Adcock, I M, Ahmed, H, Bel, Elisabeth H., Bel, Elisabeth H   +61 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Adult-onset retinoblastoma: An uncommon and challenging diagnosis

Oman Journal of Ophthalmology, 2023
Ritesh Verma, Aminder Singh, Sumeet Chopra, Yesha Gupta, Bolajoko Abidemi Adewara   +4 more
doaj   +1 more source

Resolution of adult-onset cyclic esotropia

Journal of Clinical Ophthalmology and Research
Cyclic esotropia is a rare type of strabismus that has alternating periods of esotropia and orthotropia. We present the case of a 60-year-old male who complained of inward deviation of the right eye for 8–9 years with alternating periods of 12-h ...
Chasin Riamuk Roomching, Swatishree Nayak   +1 more
doaj   +1 more source

Treatment of adult-onset Still’s disease: a review

, 2014
Yvan Jamilloux,1–3,* Mathieu Gerfaud-Valentin,1,* Thomas Henry,3 Pascal Sève1 1Department of Internal Medicine, Hôpital de la Croix-Rousse, Université Claude Bernard-Lyon 1, Lyon, France; 2Department of Biochemistry ...
Henry T, Jamilloux Y, Sève P, Gerfaud-Valentin M   +3 more
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source