Results 61 to 70 of about 906,055 (304)

A case report of a man with adult-onset idiopathic hypogonadotrophic hypogonadism

, 2017
Background Adult-onset idiopathic hypogonadotrophic hypogonadism is a rare condition. It includes men who have no recognizable central nervous system abnormality nor other identifiable cause. They generally demonstrate age-appropriate puberty and normal
Davoren, Peter, Tang, Chee
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Vitrectomy for epiretinal membrane in adult-onset Coats' disease

Indian Journal of Ophthalmology, 2017
Coats' disease is characterized by retinal vascular telangiectasia and subretinal and intraretinal exudation. A relatively benign form of the disease that occurs in adults is referred to as adult-onset Coats' disease. Involvement of macula in the form of
Pradeep Kumar, Vinod Kumar
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Profile of Patients with Seizure Disorders in Adults Presenting to Manipal Teaching Hospital

Journal of College of Medical Sciences-Nepal
Background Seizures can affect people of all ages, including adults. Symptoms of seizures can vary widely, including muscle convulsions, loss of consciousness, staring spells, confusion, repetitive movements, and sensory disturbances.
Bishnu jwarchan, Durga Dhungana, Anil Dhakal, Ramesh Raj Acharya, Nikunja Yogi   +4 more
doaj   +1 more source

A Novel Mutation of GFAP Causing Adult-Onset Alexander Disease

Frontiers in Neurology, 2019
Alexander disease (AxD) is a rare, autosomal dominant neurological disorder. Three clinical subtypes are distinguished based on age at onset: infantile (0–2 years), juvenile (2–13 years), and adult (>13 years).
Andrea Ciammola, Davide Sangalli, Jenny Sassone, Jenny Sassone, Barbara Poletti, Laura Carelli, Paolo Banfi, Gabriele Pappacoda, Isabella Ceccherini, Alice Grossi, Luca Maderna, Monica Pingue, Monica Pingue, Floriano Girotti, Vincenzo Silani, Vincenzo Silani   +15 more
doaj   +1 more source

Methicillin-resistant Staphylococcus aureus-related Septic Pulmonary Embolism and Sacroiliitis Treated with Long-term Linezolid in a Patient with Adult-onset Still's Disease

, 2014
We herein report the case of a 21-year-old woman with refractory adult-onset Still's disease who developed central venous catheter-related methicillin-resistant Staphylococcus aureus sepsis during aggressive immunosuppressive therapy.
Kawashiri, Shin-ya, Horai, Yoshiro, Nakashima, Yoshikazu, Kawakami, Atsushi, Origuchi, Tomoki, Iwamoto, Naoki, Tamai, Mami, Nakamura, Hideki, Kohno, Shigeru, Izumikawa, Koichi, Oka, Satoru, Nakajima, Hideki, Ichinose, Kunihiro, Suzuki, Takahisa   +13 more
core   +1 more source

Atopic dermatitis in young adult italian males: persistent and adult-onset varieties did not differ clinically and as for allergological variables.

, 2020
BACKGROUND The prevalence of adult atopic dermatitis (AD) in general population range from 2.6% to 8% according to objective diagnosis in selected groups of people. The adult-onset AD is the clinical form arising de novo in adulthood.
Crociata, Filippo, Ingordo, Vito, Cusano, Francesco, Cazzaniga, Simone, Barbierato, Mauro, Naldi, Luigi, Perrucci, Salvatore   +6 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The diagnosis and management of congenital and adult-onset hyperinsulinism (nesidioblastosis) – literature review

, 2017
Congenital and adult-onset hyperinsulinism (CHI) must be taken under consideration in the differential diagnosis of hypoglycaemia symptoms with endogenous hyperinsulinism, especially in cases in which there was failure to find an insulinoma. Histological
Andrzej Marszałek, Adam M. Kowalewski, Łukasz Szylberg, Anna Kasperska   +3 more
core   +1 more source