Results 51 to 60 of about 906,055 (304)

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups [PDF]

, 2010
Meta-analyses of population-based genome-wide association studies (GWAS) in adults have recently led to the detection of new genetic loci for obesity. Here we aimed to discover additional obesity loci in extremely obese children and adolescents.
Marjo-Riitta Jarvelin, Martin Klingenspor, Heude, Barbara, Lévy-Marchal, C., Wichmann HE, Balkau, B, Hebebrand, J., Schürmann, A., Kiess, W., Fromme Tobias, Hartikainen, A.L., Rosskopf D, Erbel, R., Schulz N, Klingenspor Martin, Wichmann, H.-E., Schäfer H, Illig Thomas, Joeckel, Karl-Heinz, Fisher E, Johannes Hebebrand, Vogel, Carla I. G., Schulz, N, Jacques Weill, Hartikainen Anna-Liisa, Körner, A, Nöthen, MM, Krude Heiko, Borte, M, Scherag André, Froguel Philippe, Winfried Rief, Hinney A, Nöthen, M.M., Klingenspor, Martin, Hartikainen AL, Boeing Heiner, Schaefer, Helmut, Schulz, N., Rayner, Nigel W., Borte, Michael, Balkau, B., Rosskopf Dieter, Moebus, Susanne, Heinrich, Joachim, Harald Grallert, Hebebrand J, Heinrich, J., Thomas W Mühleisen, Rzehak, Peter, Klingenspor, M, Scherag S, Grallert, H., Hinney, A., Fromme, T., Vogel CI, Moebus, S, Rayner NW, Erbel, R, Dieter Rosskopf, Reinehr, T., Hartikainen, Anna-Liisa, Scherag A, Vogel, CIG, Eva Fisher, Jarvelin, Marjo-Riitta, Hartikainen, AL, Biebermann, Heike, Mühleisen TW, Vatin, V, Noethen, Markus M., Nigel W Rayner, Wichmann, H-E, Grallert H, Inga Prokopenko, Dina, C., Jarick Ivonne, Rief W, Vogel, CI, Mueller, Timo D., Prokopenko I, Berdel Dietrich, David Meyre, Berdel, D., Jarvelin, M.R., Hebebrand, Johannes, Borte Michael, Reinehr, T, Schulz Nadja, Grallert, Harald, Jarvelin, M-R, Vatin, Vincent, Joeckel, K-H, Schaefer, H, Meyre D, Jarvelin MR, Fisher Eva, Boes Tanja, Heude, B, Fisher, E, Levy-Marchal, Claire, Heiko Krude, Vogel, C.I.G., Borte M, McCarthy, MI, Koerner, Antje, Karl-Heinz Jöckel, McCarthy Mark I., Boeing H, Noethen, MM, Erbel, Raimund, Wichmann, HE, Heinrich, J, Illig T, Peter Rzehak, Jarvelin Marjo-Riitta, Mýhleisen TW, Grallert Harald, Thomas Illig, Weill, J, Levy-Marchal, C, Heude Barbara, Kovacs Peter, Jöckel, KH, Kovacs, P, Heude B, Prokopenko, Inga, Meyre, David, Rzehak Peter, Fromme, Tobias, Vogel Carla I. G., McCarthy, Mark I., Krude, H, Berdel, D, Kiess, W, Mühleisen Thomas W., Rief, W., Froguel P, Boeing, Heiner, Claire Levy-Marchal, McCarthy MI, Biebermann H, Illig, T, Mueller, TD, Christian Rimmbach, Scherag Susann, Tanja Boes, Carla I G Vogel, Vatin, V., Fisher, Eva, Heude, B., Prokopenko, I, Heike Biebermann, Reinehr Thomas, Hinney, A, Ivonne Jarick, Heiner Boeing, Christian Dina, Moebus, S., Delplanque J, Kovacs, P., Dina Christian, Fromme T, Illig, T., Weill, Jacques, Rosskopf, Dieter, Fisher, E., Reinehr, Thomas, Jöckel KH, Boes, T, Nadja Schulz, Kovacs, Peter, Moebus S, Schýrmann A, Muehleisen, TW, Heinrich Joachim, Raimund Erbel, Rosskopf, D., Prokopenko, I., Körner Antje, Scherag, Susann, Rimmbach, Christian, Dina C, Antje Körner, Koerner, A, Hebebrand, J, Scherag, S., Scherag, A, Rzehak, P., Thomas Reinehr, Rief, Winfried, Boeing, H, Reinehr T, Klingenspor M, Helmut Schäfer, Scherag, S, Schäfer, H, H-Erich Wichmann, Schäfer, H., Hebebrand Johannes, Meyre David, Rayner, N.W., Kiess, Wieland, Anke Hinney, Hinney Anke, Scherag, Andre, Meyre, D, Rosskopf, D, Hinney, Anke, Biebermann, H., Susanne Moebus, Körner A, Scherag, A., Levy-Marchal C, Müller, T.D., Delplanque, Jerome, Rief Winfried, Muehleisen, Thomas W., Müller TD, Krude, H., Rimmbach, C, Jöckel, K.-H., Rzehak P, Berdel D, Philippe Froguel, Biebermann, H, Wichmann, Heinz-Erich, Rief, W, Anna-Liisa Hartikainen, Barbara Heude, McCarthy, M.I., Jarvelin, MR, André Scherag, Jérôme Delplanque, Rayner, NW, Boes, T., Jarick I, Beverley Balkau, Rimmbach, C., Mühleisen, T.W., Mühleisen, TW, Vatin Vincent, Vincent Vatin, Hartikainen, A-L, Moebus Susanne, Schürmann, A, Delplanque, J, Michael Borte, Balkau, Beverley, Susann Scherag, Boes T, Balkau Beverley, Jarick, Ivonne, Boes, Tanja, Müller, TD, Prokopenko Inga, Borte, M., Annette Schürmann, Krude H, Berdel, Dietrich, Nöthen Markus M., Jarick, I, Müller Timo D., Schulz, Nadja, Wichmann H.-Erich, Dina, Christian, Dina, C, Mýller TD, Froguel, Philippe, Weill Jacques, Fromme, T, Rimmbach C, Grallert, H, Schuermann, Annette, Mark I McCarthy, Schäfer Helmut, Weill, J., Delplanque Jérôme, Rayner Nigel W., Kiess Wieland, Illig, Thomas, Timo D Müller, Joachim Heinrich, Balkau B, Vatin V, Tobias Fromme, Rzehak, P, Schürmann Annette, Kiess W, Körner, A., Nöthen MM, Levy-Marchal Claire, Kovacs P, Markus M Nöthen, Erbel Raimund, Wieland Kiess, Erbel R, Heinrich J, Dietrich Berdel, Klingenspor, M., Jarick, I., Schürmann A, Rimmbach Christian, Boeing, H., Froguel, P., Peter Kovacs, Krude, Heiko, Weill J, Schuermann, A, Delplanque, J., Jöckel Karl-Heinz, Biebermann Heike, Meyre, D., Froguel, P   +313 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Adult-onset Still's disease

Autoimmunity Reviews, 2014
First described in 1971, adult-onset Still's disease (AOSD) is a rare multisystemic disorder considered as a complex (multigenic) autoinflammatory syndrome. A genetic background would confer susceptibility to the development of autoinflammatory reactions to environmental triggers.
Gerfaud-Valentin, Mathieu, Jamilloux, Yvan, Iwaz, Jean, Sève, Pascal   +3 more
openaire   +5 more sources

Adult-onset mitochondrial myopathy [PDF]

Postgraduate Medical Journal, 1992
Summary Mitochondrial diseases are polymorphic entities which may affect many organs and systems. Skeletal muscle involvement is frequent in the context of systemic mitochondrial disease, but adult-onset pure mitochondrial myopathy appears to be rare.
J, Fernandez-Sola, J, Casademont, J M, Grau, F, Graus, F, Cardellach, E, Pedrol, A, Urbano-Marquez   +6 more
openaire   +2 more sources

Case report Adult-onset Still’s disease as a mask of Hodgkin lymphoma

, 2015
Adult-onset Still’s disease is a rare disorder, which creates difficulties in making a proper diagnosis. Ambiguous symptoms and results of auxiliary tests, lack of unequivocal diagnostic tests and the need to exclude other causes of the disease are major
Katarzyna Pawlak-Buś, Piotr Leszczyński, Ewa Dudziec   +2 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Adult onset xantogranulomatous disease associated with vitiligo

Indian Dermatology Online Journal, 2019
Adult Onset Xanthogranulomatous Disease represents an umbrella term encompassing 4 distinct entities with partially overlapping clinicopathological features: adult-onset xanthogranuloma, adult-onset asthma with periocular xanthogranuloma, Erdheim-Chester
Rashmi Sriram, Rajendra Okade, T A Sushma   +2 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Recurrent pneumonia with mild hypogammaglobulinemia diagnosed as X-linked agammaglobulinemia in adults

Respiratory Research, 2001
Background X-linked agammaglobulinemia (XLA) is a humoral immunodeficiency caused by disruption of the Bruton's tyrosine kinase (BTK) gene. Typical XLA patients suffer recurrent and severe bacterial infections in childhood.
Tsuchiya Shigeru, Miyawaki Toshio, Tsukada Satoshi, Hagiwara Koichi, Tazawa Ryushi, Sasahara Yoji, Usui Kazuhiro, Nukiwa Toshihiro   +7 more
doaj   +1 more source