Results 101 to 110 of about 1,887,897 (253)

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Adult Learning and Critical Contemplative Pedagogy in Higher Education

, 2020
This chapter provides a philosophical understanding about the theory of knowledge and the role it plays in institutions of higher education in Western culture.
Krikorian, Maryann, Maryann Krikorian
core   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Feminist pedagogy and adult learning : Underlying theory and emancipatory practice

, 1996
This paper examines the theoretical underpinnings of various trends of feminist pedagogy and its relationship to adult learning around issues of the construction of knowledge, authority, voice, and dealing with ...
Tisdell, Elizabeth J.
core  

Between Immigration Control and Child Protection: Unaccompanied Minors in Belgium

Social Work and Society, 2017
This article describes the situation of Unaccompanied Minors (UAM) in Belgium, both in terms of their numbers and demographic profile and in terms of their health and educational challenges. It sketches the complex Belgian legal and policy framework that
Katrien De Graeve, Marianne Vervliet, Ilse Derluyn   +2 more
doaj  

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

Advanced Science, EarlyView.
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley   +1 more source

Work-based learning as critical social pedagogy

, 2001
This paper reports research conducted by the Research Centre for Learning and Social Transformation (CLAST). Its work on work-based learning reframes the dualism of higher education and vocational education and training within a critical social pedagogy ...
Wagner, Regine, Childs, Merilyn, Houlbrook, Michael C.   +2 more
core  

Medical Education Meets Modern Pedagogy: Medical Students Perspective

Journal of Nepal Medical Association
The principles of adult learning have significantly transformed medical education, moving away from traditional lecture-based methods to a more interactive, self-directed, and problem-centered approach.
Sandip Bhusal, Aashis Poudel
doaj   +1 more source

Universal Battery Capacity Degradation Forecasting Driven by Foundation Models Across Diverse Chemistries and Conditions

Advanced Science, EarlyView.
A unified time‐series forecasting framework learns transferable battery capacity‐degradation patterns from 20 heterogeneous datasets spanning chemistries, formats, temperatures, and cycling conditions. A single model delivers competitive predictions on both known and previously unseen datasets, while physics‐guided representation learning improves ...
Joey Chan, Huan Wang, Zhen Chen, Haoyu Pan, Wei Wu, Zirong Wang, Ershun Pan, Min Xie, Lifeng Xi   +8 more
wiley   +1 more source

A multimodal social semiotic approach to jewellery design pedagogy [PDF]

, 2012
Includes abstract.Includes bibliographical references.This thesis presents a multimodal social semiotic theoretical framework to explore jewellery design pedagogy.
Salaam, Safia
core   +1 more source