Results 151 to 160 of about 6,390,087 (296)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

High-resolution mapping of Yr78, an adult plant resistance gene to wheat stripe rust. [PDF]

Plant Genome, 2022
Dang C, Zhang J, Dubcovsky J.
europepmc   +1 more source

Inheritance of resistance to Chinese stripe rust on Australian wheat variety Sunco

, 2006
Australian wheat variety Sunco carry good adult plant resistance to Chinese stripe rust races CY32. Wheat variety Chuanyu12 released in Sichuan province is terrible adult plant susceptible.
Zou, Yuchun, Yang, Ennian, Yang, Wuyun, Sutherland, Mark   +3 more
core  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

A seven-year assessment of resistance durability to yellow rust in some wheat cultivars in Ardabil province, Iran

Journal of Crop Protection, 2017
Yellow (stripe) rust caused by Puccinia striiformis f. sp. tritici is an important disease that threatens wheat production where the weather conditions are congenial and susceptible cultivars are present.
Safarali Safavi, Farzad Afshari
doaj  

Introgression of the bread wheat D genome encoded Lr34/Yr18/Sr57/Pm38/Ltn1 adult plant resistance gene into Triticum turgidum (durum wheat). [PDF]

Theor Appl Genet, 2023
Li H, Zhang P, Luo M, Hoque M, Chakraborty S, Brooks B, Li J, Singh S, Forest K, Binney A, Zhang L, Mather D, Ayliffe M.   +12 more
europepmc   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

QTL Mapping of Adult Plant Resistance to Stripe Rust in a Doubled Haploid Wheat Population. [PDF]

Front Genet, 2022
Tehseen MM, Tonk FA, Tosun M, Randhawa HS, Kurtulus E, Ozseven I, Akin B, Nur Zulfuagaoglu O, Nazari K.   +8 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source