Results 81 to 90 of about 6,390,087 (296)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

INHERITANCE OF ADULT PLANT STRIPE RUST RESISTANCE IN WHEAT CULTIVARS GIZA160 AND GIZA168 [PDF]

Journal of Plant Protection and Pathology, 2015
This investigation was carried out at the experimental farm of Sakha Agricultural Research Station, during wheat growing seasons from 2009 to 2011. The objectives were to study the inheritance of adult plant resistance to stripe rust Puccinia striiformis
Kh. Ragab, A. Shahin
doaj   +1 more source

Inheritance of Adult Plant Leaf Rust Resistance in the Brazilian Wheat Cultivar Toropi [PDF]

Plant Disease, 2000
Adult plant resistance to leaf rust in the Brazilian wheat cultivar Toropi (Triticum aestivum) was studied in crosses with the susceptible cultivar IAC 13. Cvs. Toropi and IAC 13 are susceptible at the seedling stage to race LCG-RS of Puccinia triticina Erikss., and to all other known Brazilian leaf-rust races.
A L, Barcellos, A P, Roelfs, M I B, de Moraes-Fernandes   +2 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Powdery Mildew and Aphid Resistance in Wheat–Thinopyrum intermedium Derivatives from Zhong Backgrounds

Plants
A total of 159 wheat–Thinopyrum intermedium derivatives, originating from six Zhong partial amphiploids, were evaluated for resistance to powdery mildew (Blumeria graminis f. sp.
Qing Guo, Liangxi Zhu, Huihui Wang, Guanlin Liu, Chahong Yan, Yanming Zhang, Yu Sun, Hongjie Li, Lei Cui   +8 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Evaluation of stripe rust resistance and genome-wide association study in wheat varieties derived from the International Center for Agricultural Research in the Dry Areas

Frontiers in Plant Science
159 wheat varieties obtained from ICARDA, CYR32, CYR33 and CYR34 were used to evaluate the stripe rust resistance in this study. Seedling resistance was carried out in the green house at the two-leaf stage.
Zhonghao Gao, Xin Wang, Yunxiang Li, Wanwei Hou, Wanwei Hou, Xiaojuan Zhang   +5 more
doaj   +1 more source

Genome-Wide Mapping of Quantitative Trait Loci Conferring All-Stage and High-Temperature Adult-Plant Resistance to Stripe Rust in Spring Wheat Landrace PI 181410

, 2020
Stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is one of the most destructive diseases of wheat in the world. Genetic resistance is the best strategy for control of the disease.
Yan Liu, Yanmin Qie, Xianming Chen, Meinan Wang, Xing Li   +4 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source