Results 111 to 120 of about 13,262 (261)

The impact of community children's playgrounds on neighborhood interactions and residents' mental health from an all-age sharing perspective

Frontiers in Public Health
BackgroundThe outbreak of COVID-19 and rapid urbanization in China have put mental health at the forefront of societal concerns. Despite extensive studies on how community environments influence residents' mental health, the mechanisms underlying how ...
Yilin Jin, Yuetong Wang, Ning Sun, Linquan Chen, Zhenhua Zheng   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Factors in adult children that influence and motivate care giving for parents with dementia

, 2010
This systematic review evaluated research on adult children of parents with dementia who were primary carers and the possible psychological predictors of carer burden. Searches were undertaken from January 2004 to October 2008.
Dodge, Suzanne
core  

A longitudinal comparative study of the physical and mental health problems of affected residents of the firework disaster Enschede, The Netherlands

, 2007
Objectives: After the firework disaster in Enschede, The Netherlands, on 13 May 2000, a longitudinal health study was carried out. Study questions were: (1) did the health status change over this period; and (2) how is the health status 18months after ...
Gersons, B.P.R., Kleber, R.J., Gersons, B. P. R., Kleber, R. J., Velden, P.G. van der, Lebret, E., Grievink, L, van der Velden, P. G., Stellato, R.K., Stellato, R. K., Dusseldorp, A., Grievink, L.   +11 more
core   +1 more source

Impact pathways of personality and psychosocial stress on depression among adult community residents in China: a fuzzy-set qualitative comparative analysis

Frontiers in Psychology
ObjectiveDepression is a common mental illness with a high prevalence rate and is a significant contributor to the global burden of diseases. Various factors are associated with depression, and its etiology is complex.
Xi Yang, Liuruyu Yu, Shengming Zhang, Zhaoguo Wei, Gaoqiang Xie, Gaoqiang Xie, Jianhong Wang   +6 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Population Annoyance by Below-Limit Industrial Noise from the Mining Industry: A Questionnaire Survey Methodology

Noise and Health
Objective: The operation of open-pit mines relies on powerful equipment that produces noise emissions reaching up to 120 dB. Populations living in the vicinity of mines often complain about noise even when the noise levels are below the permissible ...
Markéta Stanovská, Hana Šlachtová, Ľubica Argalášová, Dana Potužníková, Hana Tomášková   +4 more
doaj   +1 more source

Retirement residence living: stories of older adult residents

, 2019
Social isolation and loneliness have a negative effect on the lives of older adults. Participation in regular physical activity may facilitate social connectedness to mitigate feelings of social isolation and loneliness. Current understanding of regular physical activity for social connection and health benefits in older adult residents of retirement ...
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source