Results 81 to 90 of about 4,444,458 (302)

Wide Variability of Pediatric Knee Arthroscopy Case Volume in Orthopaedic Surgery Residency

open access: yesArthroscopy, Sports Medicine, and Rehabilitation, 2021
Purpose: The purpose of this study was to evaluate orthopaedic surgery resident case volume and variability for adult and pediatric knee arthroscopy from 2016 to 2020.
Suleiman Y. Sudah, M.D.   +6 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

The knee osteoarthritis prevalence and associated influencing factors among adult residents in Urumqi city

open access: yesZhongguo gonggong weisheng
ObjectiveTo investigate the prevalence of knee osteoarthritis (KOA) and its influencing factors among adult residents in Urumqi city, Xinjiang, and to provide a reference for the prevention and control of KOA.
Lingyun SHI   +6 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

A prospective cohort study on the impact of healthy lifestyles on all-cause and cardiovascular disease mortality among adult residents in Guizhou province

open access: yesZhongguo gonggong weisheng
ObjectiveTo investigate the impact of healthy lifestyles on all-cause and cardiovascular disease (CVD) mortality among adult residents in Guizhou province, and to provide a reference for reducing mortality risk in the local population.
Jie ZHOU   +7 more
doaj   +1 more source

Urban Open Space Is Associated with Better Renal Function of Adult Residents in New Taipei City

open access: yesInternational Journal of Environmental Research and Public Health, 2019
The purpose of this study is to explore the association between proximity to open space and adult renal function. This was a cross-sectional study. Adult residents of Taipei metropolis were recruited in the analysis. The proximity of each subject to open
J. Chien   +4 more
semanticscholar   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Impact of healthy lifestyle on diabetes incidence among adults of different socioeconomic status in Guizhou province: a prospective cohort study

open access: yesZhongguo gonggong weisheng
ObjectiveTo understand the impact of healthy lifestyle on diabetes incidence among adults with different socioeconomic status (SES) in Guizhou province and provide reference for diabetes prevention and control. MethodsA total of 9 280 permanent residents
Yiying WANG   +7 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Salt intake and its influencing factors among adult residents in rural areas of Hebei province

open access: yesZhongguo gonggong weisheng
ObjectiveTo investigate the salt intake status and its influencing factors among adult residents in rural areas of Hebei province, and to provide a reference for developing salt reduction interventions for residents in this area.
Di YANG   +5 more
doaj   +1 more source

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