Results 111 to 120 of about 235,905 (295)

Disrupting the Path from Childhood Trauma to Juvenile Justice: An Upstream Health and Justice Approach [PDF]

open access: yes, 2016
A groundbreaking public health study funded by the U.S. Centers for Disease Control and Prevention (CDC) and the Kaiser Foundation found astoundingly high rates of childhood trauma, including experiences like abuse, neglect, parental substance abuse ...
Cannon, Yael, Hsi, Andrew
core   +2 more sources

A proposal for a brief-term post-adoption intervention in the attachment-perspective. A single case study with a late-adopted child and his adoptive mother [PDF]

open access: yes, 2016
A growing body of attachment literature has focused on bridging the gap between research and clinical applications, even in clinical work with adoptive families.
D'Onofrio, Ester   +3 more
core   +2 more sources

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

open access: yesAdvanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du   +5 more
wiley   +1 more source

From motherhood to maternal subjectivity [PDF]

open access: yes, 2001
In this paper I try to work out what would be involved - and what would be some of the implications - in moving from the idea of motherhood to maternal subjectivity (which I theorise through the lens of unconscious intersubjectivity). Motherhood connotes
Hollway, Wendy
core  

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

open access: yesAdvanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang   +12 more
wiley   +1 more source

The effect of 4-weeks voluntary exercise on separation anxiety disorder in rats [PDF]

open access: yesفصلنامه ابن سینا, 2019
Background: Separation anxiety is the most common anxiety disorder in children. The neglected treatment of this disorder at early ages may be a risk factor for other childhood and adult psychological disorders.
F Zolfaghari, maghsoud peeri
doaj  

Early-life stress, microbiota, and brain development: probiotics reverse the effects of maternal separation on neural circuits underpinning fear expression and extinction in infant rats

open access: yesDevelopmental Cognitive Neuroscience, 2019
Early-life stress has pervasive, typically detrimental, effects on physical and mental health across the lifespan. In rats, maternal-separation stress results in premature expression of an adult-like profile of fear regulation that predisposes stressed ...
Caitlin S.M. Cowan   +2 more
doaj   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu   +6 more
wiley   +1 more source

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