Results 111 to 120 of about 348,931 (312)

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Current perspectives on the role of oxytocin receptor (OXTR) gene variants in panic disorder: associations with disease liability and separation anxiety

Archives of Medical Science
Introduction Oxytocin receptor (OXTR) gene variations are associated with empathy, trust, emotional stability, stress reactivity, social bonding and attachment behaviors.
Zeynep Yegin, Gokhan Sarisoy, Ahmet Uzun, Yasin Altinisik   +3 more
doaj   +1 more source

Early handling and repeated cross-fostering have opposite effect on mouse emotionality [PDF]

, 2015
Early life events have a crucial role in programming the individual phenotype and exposure to traumatic experiences during infancy can increase later risk for a variety of neuropsychiatric conditions, including mood and anxiety disorders.
Battaglia, M, CENTOFANTE, ELEONORA, D'Amato, F.r., Felsani, A, Lampis, V, LUCHETTI, ALESSANDRA, ODDI, DIEGO   +6 more
core   +2 more sources

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

Predictive values of early parental loss and psychopathological risk for physical problems in early adolescents [PDF]

, 2018
Background: Several studies have suggested that the early loss of parents is a potentially traumatic experience, exposing adolescents to a higher risk for the onset of psychopathological symptoms.
Ballarotto, Giulia, Cerniglia, Luca, Cimino, Silvia, Marzilli, Eleonora, Tafà, Mimma, Tambelli, Renata   +5 more
core   +2 more sources

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

With a little help from FUN FRIENDS young children can overcome anxiety [PDF]

, 2014
This paper highlights resilience as a key concept when working with young children to improve their emotional wellbeing and reduce anxieties. Supporting children aged 4-7 years with anxiety is a significant area of advancement in terms of therapeutic ...
Carlyle, Donna
core  

Адаптация теста сепарационной тревоги взрослых ASA-27 (Adult Separation Anxiety Questionnaire) на российской выборке

Психологические исследования, 2016
Представлены результаты адаптации опросника ASA-27 (Adult Separation Anxiety Questionnaire) на российской популяции. Приведены психометрические характеристики методики, а также определены корреляции уровня сепарационной тревоги с возрастом и полом ...
Анастасия Дитюк
semanticscholar   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Separation Anxiety and Depressive Symptoms in Latin-American University Students: the role of Interpersonal Problem Areas

Mediterranean Journal of Clinical Psychology
Background: Research on depressive symptoms and interpersonal issues in foreign university students (FS) remains limited. This study assessed interpersonal problem areas, depressive symptoms, and adult separation anxiety (ASA) in Latin-American FS ...
Mario Miniati, Graziella Orrù, Giorgia Papini, Stephanie Vergara-Aizprua, Rebecca Ciacchini, Laura Palagini, Ciro Conversano, Angelo Gemignani   +7 more
doaj   +1 more source