Results 71 to 80 of about 21,627 (289)

Return to work after adult spinal deformity surgery.

, 2023
PurposeTo determine the proportions of patients returning to work at various points after adult spinal deformity (ASD) surgery and the associations between surgical invasiveness and time to return to work.MethodsUsing a multicenter database of patients ...
Bess, Shay, Harris, Andrew B, Wang, Michael, Passias, Peter G, Kebaish, Khaled M, Wang, Kevin Y, Hostin, Richard A, Ames, Christopher P, Raad, Micheal, Protopsaltis, Themisctocles S, Klineberg, Eric O, Hart, Robert, Neuman, Brian J, Gupta, Munish C, International Spine Study Group   +14 more
core   +1 more source

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Classification of Adult Spinal Deformity: Review of Current Concepts and Future Directions

Spine Surgery and Related Research, 2019
Although adult spinal deformity (ASD) has become a global health problem, the classification system and optimal surgical treatment for ASD is yet to be standardized worldwide.
Laxmikant Dagdia, Terufumi Kokabu, Manabu Ito   +2 more
doaj   +1 more source

Cost-Effectiveness in Adult Spinal Deformity Surgery [PDF]

Neurosurgery, 2018
Abstract The complexity and heterogeneity of adult spinal deformity (ASD) creates significant difficulties in performing high-quality, complete economic analyses. For the same reasons, however, such studies are immensely valuable to clinicians and health policy experts.
Grigoriy G, Arutyunyan, Peter D, Angevine, Sigurd, Berven   +2 more
openaire   +2 more sources

Reaching the medicare allowable threshold in adult spinal deformity surgery: multicenter cost analysis comparing actual direct hospital costs versus what the government will pay.

, 2023
Study designRetrospective multicenter cost analysis.ObjectiveTo (1) determine if index episode of care (iEOC) costs of Adult Spinal Deformity (ASD) surgeries are below the Medicare Allowable (MA) threshold, and (2) identify variables that can predict ...
Gum, Jeffrey L, Yeramaneni, Samrat, Lafage, Virginie, Passias, Peter G, Hostin, Richard A, Line, Breton, Glassman, Steven D, Ames, Christopher P, Burton, Douglas L, Shaffrey, Christopher I, Shay Bess, R, International Spine Study Group, Smith, Justin S, Carreon, Leah Y   +13 more
core   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Late Complications and Adverse Events in Adult Deformity Surgery: A Narrative Review of Event Types, Prevalence, and Information Gaps

Global Spine Journal
Study Design Literature review. Objectives The purpose of this paper is to provide a narrative review of late complications in adult deformity surgery, including infection, pseudarthrosis and junctional pathology after deformity correction.
Sigurd H. Berven MD, Justin S. Smith MD, John T. Street MD, PhD, Eric Klineberg MD, Yong Qiu MD, Aboubacar Wague BA, Stephen J. Lewis MD, MSc   +6 more
doaj   +1 more source

Predictors of Health-Related Quality-of-Life After Complex Adult Spinal Deformity Surgery: A Scoli-RISK-1 Secondary Analysis.

, 2023
Study designLongitudinal cohort.ObjectivesTo identify variables that predict 2-year Short Form-36 Physical Composite Summary Score (SF-36PCS) and the Scoliosis Research Society-22R (SRS22-R) Total score after surgery for complex adult spinal deformity ...
Schwab, Frank J, Mehdian, Hossein, Matsuyama, Yukihiro, Kebaish, Khaled M, Lenke, Lawrence G, Glassman, Steven D, Ames, Christopher P, Fehlings, Michael G, Shaffrey, Christopher I, Pellisé, Ferran, Qiu, Yong, Carreon, Leah Y, Dahl, Benny, Cheung, Kenneth MC   +13 more
core   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Personalizing adult spinal deformity surgery through multimodal artificial intelligence

To achieve meaningful, patient-centered outcomes following adult spinal deformity (ASD) surgery, it is crucial to engage in precise preoperative planning, perform excellent intraoperative execution, and ensure careful postoperative management.
Christopher P. Ames, Tej D. Azad, Vikas N. Vattipally   +2 more
core   +1 more source