Results 81 to 90 of about 21,627 (289)

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Unplanned Readmission Following Early Postoperative Complications After Fusion Surgery in Adult Spine Deformity: A Multicentric Study

Global Spine Journal, 2023
Study Design: Multicentric retrospective study, Level of evidence III. Objective: The objective of this multicentric study was to analyze the prevalence and risk factors of early postoperative complications in adult spinal deformity patients treated with
Gaston Camino-Willhuber MD, Alfredo Guiroy MD, Mariano Servidio MD, Nelson Astur MD, Fernando Nin-Vilaró MD, Fernando Alvarado-Gomez MD, Murilo Daher MD, Bruno Saciloto MD, Allan Ono MD, Olavo Letaif MD, Baron Zarate-Kalfopulos MD, Ratko Yurac MD, Emiliano Vialle MD, Marcelo Valacco MD   +13 more
doaj   +1 more source

Development and Validation of a Multidomain Surgical Complication Classification System for Adult Spinal Deformity.

, 2021
Study designProspective analysis of example cases.ObjectiveThe aim of this study was to analyze the accuracy and repeatability of a new comprehensive classification system for capturing complications data in adult spinal deformity.Summary of background ...
Wick, Joseph B, Yilgor, Caglar, Lafage, Virginie, Lewis, Stephen, Schwab, Frank, Bess, Shay, Berven, Sigurd, Haddad, Sleiman, Lenke, Lawrence G, Pellise, Ferran, Núñez-Pereira, Susana, Lafage, Renaud, Gupta, Munish, Shaffrey, Christopher, Klineberg, Eric O, Ames, Christopher, International Spine Study Group, Smith, Justin S   +17 more
core   +1 more source

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Patients with spinal deformity over the age of 75: a retrospective analysis of operative versus non-operative management.

, 2023
PurposeThe goal of the present study was to compare the outcomes of operative and non-operative patients with adult spinal deformity (ASD) over 75 years of age.MethodsA retrospective review of a multicenter prospective adult spinal deformity database was
Lafage, Virginie, Mundis, Gregory M, Bess, Shay, Schwab, Frank, Scheer, Justin K, Yurter, Alp, International Spine Study Group (ISSG), Blaskiewicz, Donald, Sciubba, Daniel M, Ames, Christopher P, Hart, Robert A, Eastlack, Robert, Gupta, Munish, Shaffrey, Christopher I, Klineberg, Eric, Protopsaltis, Themistocles S, Kebaish, Khaled, Kim, Han Jo, Smith, Justin S, Koski, Tyler   +19 more
core   +1 more source

Ultrasound‐Activated Bifunctional Piezoelectric Hydrogel Dressings Promote Infected Wound Healing via Regulating Angiogenesis and Lymphangiogenesis

Advanced Science, EarlyView.
This study developed a double‐network hydrogel with piezoelectric properties, exhibiting excellent antibacterial activity and promoting fibroblast migration, angiogenesis, and lymphangiogenesis through piezoelectric stimulation, thereby accelerating the healing of infected chronic wounds.
Xiang Li, Zhen Ding, Zhihua Liu, Hao Chen, Jianyang Shan, Yanxuan Shao, Yaling Yu, Gen Wen   +7 more
wiley   +1 more source

Application of deformity principles in the management of spinal neoplasms: A Primer

North American Spine Society Journal
: Background: With advances in surgical techniques, radiation, and systemic therapy, prognoses and quality of life have improved amongst patients with primary and metastatic vertebral column tumors.
Zach Pennington, MD, Joseph H Schwab, MD, Sheng-fu Larry Lo, MD MHS, C. Rory Goodwin, MD PhD, Matthew L Goodwin, MD PhD, Matthew Colman, MD, Raphaële Charest-Morin, MD, Nicolas Dea, MD, Daniel Lubelski, MD, Ali Ozturk, MD, Jacob M. Buchowski, MD MS, Wende Gibbs, MD, Wesley Hsu, MD, Ajit Krishnaney, MD, Ilya Laufer, MD, Mohamed Macki, MD, Addisu Mesfin, MD, Ganesh Shankar, MD PhD, Dan Tobert, MD, John Shin, MD MBA, Andrew Platt, MD, Daniel M Sciubba, MD MBA   +21 more
doaj   +1 more source

Head and pelvis are the key segments recruited by adult spinal deformity patients during daily life activities [PDF]

Functional assessment is a key element in evaluating adult spinal deformity (ASD) patients. The multitude of 3D kinematic parameters provided by movement analysis can be confusing for spine surgeons.
MEKHAEL, Elio, AYOUB, Elma, ASSI, Ayman, NASSIM, Nabil, SAADE, Maria, KARAM, Mohammad, SKALLI, Wafa, RACHKIDI, Rami, MASSAAD, Abir, BIZDIKIAN, Aren Joe, REHAYEM, Rami, RTEIL, Ali, CHAAYA, Celine, JABER, Elena, GHANEM, Ismat   +14 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Spinal cord injury in high-risk complex adult spinal deformity surgery: review of incidence and outcomes from the Scoli-RISK-1 study. [PDF]

STUDY DESIGN: Clinical case series. OBJECTIVE: To describe the cause, treatment and outcome of 6 cases of perioperative spinal cord injury (SCI) in high-risk adult deformity surgery.
Lenke, Lawrence G., Kebaish, Khaled M., Shaffrey, Christopher I., Matsuyama, Yukihiro, Badhiwala, Jetan H., Schwab, Frank, Berven, Sigurd, Carreon, Leah Y., Carreon, Leah, Lenke, Lawrence, Cheung, Kenneth, Jiang, Fan, Dekutoski, Mark, Badhiwala, Jetan, Joshi, Hetshree, Kebaish, Khaled, Dahl, Benny T., Pellisé, Ferran, Boachie-Adjei, Oheneba, Dekutoski, Mark B., Lewis, Stephen J., Qiu, Yong, Fehlings, Michael, Dahl, Benny, Mehdian, Hossein, Lewis, Stephen, Schwab, Frank J., Fehlings, Michael G., Cheung, Kenneth M.C., Ames, Christopher P., Shaffrey, Christopher, Ames, Christopher, Wilson, Jamie R.F., Berven, Sigurd H., Wilson, Jamie   +34 more
core   +3 more sources