Results 61 to 70 of about 4,997 (303)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Adult Still’s disease and Tako-Tsubo syndrome

Clinical Management Issues, 2012
Here we describe the case of a 68-year-old Italian female who was admitted in our hospital for the occurrence of arthralgia, abdominal pain and general discomfort.
Susanna Cozzio, Dimitri Peterlana, Roberto Bonmassari, Angela Zappaterra, Walter Spagnolli   +4 more
doaj   +1 more source

Baseline CXCL10 and CXCL13 levels are predictive biomarkers for tumor necrosis factor inhibitor therapy in patients with moderate to severe rheumatoid arthritis: a pilot, prospective study [PDF]

, 2016
BACKGROUND: TNF inhibitors have been used as a treatment for moderate to severe RA patients. However, reliable biomarkers that predict therapeutic response to TNF inhibitors are lacking.
Andrea Bottaro, Bobby Kwanghoon Han, Igor Kuzin, John P. Gaughan, Nancy J. Olsen   +4 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A new miniaturized system for extracorporeal membrane oxygenation in adult respiratory failure [PDF]

, 2009
Introduction Mortality of severe acute respiratory distress syndrome in adults is still unacceptably high. Extracorporeal membrane oxygenation (ECMO) could represent an important treatment option, if complications were reduced by new technical ...
Thomas Müller, Alois Philipp, Andreas Luchner, Christian Karagiannidis, Thomas Bein, Michael Hilker, Leopold Rupprecht, Julia Langgartner, Markus Zimmermann, Matthias Arlt, Jan Wenger, Christof Schmid, Günter AJ Riegger, Michael Pfeifer, Matthias Lubnow   +14 more
core   +1 more source

Adult-onset Still's disease preceding Crohn's disease [PDF]

Journal of Crohn's and Colitis, 2013
Concomitant diagnosis of Crohn's disease and juvenile or adult-onset idiopathic arthritis is rare. It is possible that both conditions share some genetic or immunological defects although sufficient data are lacking. We describe herein the first case of a patient with adult-onset Still's disease who was diagnosed on follow up with concomitant Crohn's ...
Konstantinos H, Katsanos, Vasiliki, Siozopoulou, Dimitrios, Sigounas, Vasileios E, Tsianos, Dimitrios, Christodoulou, Vasiliki, Mitsi, Epameinondas V, Tsianos   +6 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still’s disease [PDF]

, 2017
BackgroundHLA-DRB1 alleles are major determinants of genetic predisposition to rheumatic diseases. We assessed whether DRB1 alleles are associated with susceptibility to particular clinical features of adult onset Still’s disease (AOSD) in a Japanese ...
Asano Tomoyuki, Eguchi Katsumi, Fujikawa Keita, Furukawa Hiroshi, Ito Tomoyuki, Iwanaga Nozomi, Izumi Yasumori, Kawakami Atsushi, Kobayashi Daisuke, Kobayashi Hiroko, Koga Tomohiro, Migita Kiyoshi, Nakamura Tadashi, Nonaka Fumiaki, Ohira Hiromasa, Sato Shuzo, Shimizu Toshimasa, Suzuki Eiji, Tohma Shigeto, Tsuchiya Naoyuki, Ubara Yoshifumi, Ueki Yukitaka, Umeda Masataka, Watanabe Hiroshi, Yamasaki Satoshi, Yashiro Makiko, Yasunami Michio, Yoshiura Koh-ichiro, 古川 宏, 土屋 尚之   +29 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Acute liver transplantation in a 41-year-old male patient presenting symptoms of adult-onset Still's disease [PDF]

, 2011
L
Andrès E., Bywaters E.G., Coffernils M., Cush J.J., Fautrel B., Ishikawa M., Kadar J., Linde B., Mehrpoor G., Mert A., Motoo Y., Nemes B., Nemes B., Nemes B., Ogata A., Singh S., Still G.F., Taccone F.S., Takami A., Teran A., Yamaguchi M., Zhu G.   +21 more
core   +2 more sources