Results 101 to 110 of about 6,051,485 (314)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The Association Between Fruit and Vegetable Consumption and Mental Health Among Young Adults [PDF]

, 2019
While the majority of the American population is aware that fruits and vegetables can improve physical health, research also suggests that mental health may benefits as well.
Miller, Natalie
core   +2 more sources

An exploration of the value and mechanisms of befriending for older adults in England [PDF]

, 2011
Social isolation and loneliness in older adults are growing problems. Empirical research suggests that loneliness can lead to poorer health outcomes including higher mortality rates.
Chew-Graham, Carolyn, Gask, Linda, Lester, Helen, Mead, Nicky, Reilly, Siobhan   +4 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Interventions for reducing sedentary behaviour in community-dwelling older adults [PDF]

, 2017
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To identify the effects and assess the effectiveness of interventions to reduce sedentary behaviour (total sedentary time and the pattern of accumulation of sedentary
Adams, Alpass, Bankoski, Bij, Biswas, Chastin, Chastin, Chastin, Chastin, Chastin, Dogra, Dunstan, Egger, Ekelund, Gardiner, Gardner, Gomersall, Greef, Guyatt, Harvey, Harvey, Healy, Henson, Hertzog, Katzmarzyk, Kerr, King, King, Laforge, Lauder, Leask, Manns, Martin, Michie, Moher, Owen, Owen, Prince, Rezende, Rosenberg, Sedentary Behaviour Research Network, Song, Sparling, Tandon, Teychenne   +44 more
core   +2 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Surgery of the Aortic Valve Using a Minimally Invasive Approach

Український журнал серцево-судинної хірургії
Aim. The aim of this study is to present and analyze the technique of isolated aortic valve replacement (AVR) or repair via a minimally invasive approach – right anterior thoracotomy in the second intercostal space. Materials and Methods.
Oleksandr D. Babliak, Dmytro Ye. Babliak, Serhii V. Yatsuk   +2 more
doaj   +1 more source

Monitoring the South African National Antiretroviral Treatment Programme, 2003-2007: the IeDEA Southern Africa collaboration. [PDF]

, 2009
OBJECTIVES: To introduce the combined South African cohorts of the International epidemiologic Databases to Evaluate AIDS Southern Africa (IeDEA-SA) collaboration as reflecting the South African national antiretroviral treatment (ART) programme; to ...
Boulle, Andrew, Cornell, Morna, Davies, Mary-Ann, Eley, Brian, Fairall, Lara, Giddy, Janet, MacPhail, Patrick, Maxwell, Nicola, Mohapi, Lerato, Moultrie, Harry, Prozesky, Hans, Rabie, Helena, Technau, Karl, van Cutsem, Gilles, Wood, Robin   +14 more
core   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source