Results 101 to 110 of about 5,977,231 (321)
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Privacy attitudes and concerns in the digital lives of older adults: Westin's privacy attitude typology revisited [PDF]
arXiv, 2018 There is a growing literature on teenage and young adult users' attitudes toward and concerns about online privacy, yet little is known about older adults and their unique experiences. As older adults join the digital world in growing numbers, we need to gain a better understanding of how they experience and navigate online privacy.
arxiv
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Case Reports in Hematology, 2018 The programmed cell death protein-1 (PD-1) inhibitor nivolumab has been recently approved as an effective and safe treatment for patients with refractory/relapsed Hodgkin’s lymphomas. Dermatological adverse events, mainly skin rash, have been reported in
Panayotis Kaloyannidis +6 more
doaj +1 more source
Trends in Obesity Among Adults in the United States, 2005 to 2014.
Journal of the American Medical Association (JAMA), 2016 IMPORTANCE Between 1980 and 2000, the prevalence of obesity increased significantly among adult men and women in the United States; further significant increases were observed through 2003-2004 for men but not women.
K. Flegal +4 more
semanticscholar +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Demystify Adult Learning: A Social Network and Large Language Model Assisted Approach [PDF]
arXivAdult learning is increasingly recognized as a crucial way for personal development and societal progress. It however is challenging, and adult learners face unique challenges such as balancing education with other life responsibilities. Collecting feedback from adult learners is effective in understanding their concerns and improving learning ...
arxiv
THE ULTRASTRUCTURE OF ADULT VERTEBRATE PERIPHERAL MYELINATED NERVE FIBERS IN RELATION TO MYELINOGENESIS [PDF]
, 1955 J. David Robertson
openalex +1 more source
Guidelines for the Early Management of Adults With Ischemic Stroke
, 2007 Purpose— Our goal is to provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke.
H. Adams +15 more
semanticscholar +1 more source