Results 101 to 110 of about 3,775,410 (310)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Ectopic pregnancy treatment by combination therapy

Open Medicine, 2016
Detectability of early stages of ectopic pregnancies has increased due to improvements in ultrasonographic and biochemical techniques. Since the patients’ future procreative plans must be taken into consideration when commencing treatment, the goal of ...
Cymbaluk-Płoska Aneta, Chudecka-Głaz Anita, Kuźniak Sławomir, Menkiszak Janusz   +3 more
doaj   +1 more source

Rationale, design and methodology of APPROACH-IS II: International study of patient-reported outcomes and frailty phenotyping in adults with congenital heart disease.

, 2022
In recent years, patient-reported outcomes (PROs) have received increasing prominence in cardiovascular research and clinical care. An understanding of the variability and global experience of PROs in adults with congenital heart disease (CHD), however ...
Thomet, C., Ladak, L.A., Luyckx, K., Leong, M.C., Caruana, M., Menahem, S., Araujo, J.J., de Hosson, M., Sasikumar, N., Leye, M., Mandalenakis, Z., Christersson, C., Ladouceur, M., Areias, M.E., Ambassa, J.C., Goossens, E., Demir, F., Van Bulck, L., Baraona Reyes, F., Van De Bruaene, A., Gabriel, H., Amaral, F., Yadeta, D., Kim, Y., Kovacs, A.H., Ortiz, L., Thambo, J.B., Sandberg, C., Constantine, A., Johansson, B., Kaneva, A., Coats, L., Brainard, S., Enomoto, J., Boer, A., Callus, E., Mahadevan, V.S., Mwita, J.C., Giannakoulas, G., Alday, L., Zaidi, A., Windram, J., Moon, J.R., Cedars, A., Andresen, B., Fernandes, S.M., Rutz, T., Lykkeberg, B., Taunton, M., Khairy, P., Bouchardy, J., Moons, P., Saidi, A., Mattsson, E., Jackson, J.L., Amedro, P., Wang, J.K.   +56 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Psychotropic medications compliance review

, 2008
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on Oct.

core  

Sense of Coherence and Four-Year Caries Incidence in Finnish Adults

, 2012
This study assesses whether sense of coherence (SOC) predicts incidence of tooth decay over 4 years and the role of dental behaviours in explaining the effect of SOC on incidence of tooth decay.
Bernabé, E, Aromaa, A, Newton, J. T., Suominen, A. L., Bernabe, E., Suominen, A L, Uutela, A., Aromaa, A., Uutela, A, Newton, J T; id_orcid   +9 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Adult flatfoot

Orthopaedics & Traumatology: Surgery & Research, 2015
Adult flatfoot is defined as a flattening of the medial arch of the foot in weight-bearing and lack of a propulsive gait. The 3 lesion levels are the talonavicular, tibiotarsal and midfoot joints. The subtalar joint is damaged by the consequent rotational defects.
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source