Results 251 to 260 of about 10,055,911 (359)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Neonatal melanocortin receptor agonist treatment reduces play fighting and promotes adult attachment in prairie voles in a sex-dependent manner

, 2014
Catherine Barrett, Meera E. Modi, Billy C. Zhang, Hasse Walum, Kiyoshi Inoue, Larry J. Young   +5 more
openalex   +1 more source

Interventions for latent autoimmune diabetes (LADA) in adults.

Cochrane Database of Systematic Reviews, 2011
S. Brophy, H. Davies, Sopna Mannan, H. Brunt, Rhys Williams   +4 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Breaking the silence on late-life depression: uncovering the drivers of help-seeking in Türkiye's ageing population. [PDF]

BMC Geriatr
Ercan U, Apaydın E, Alkan Ö.
europepmc   +1 more source

Trends in Obesity Among Adults in the United States, 2005 to 2014.

Journal of the American Medical Association (JAMA), 2016
K. Flegal, D. Kruszon-Moran, M. Carroll, C. Fryar, Cynthia L Ogden   +4 more
semanticscholar   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Altered Coding of Environmental Boundaries in Human Aging: An fMRI Study. [PDF]

Hippocampus
Segen V, Stangl M, Shine J, Wolbers T.
europepmc   +1 more source

Recommendations for Management of Acute Pharyngitis in Adults

, 2015
Josep M. Cots, Juan-Ignacio Alós, Mario Bárcena, Xavier Boleda, José L. Cañada, Niceto Gómez, Ana Maria Mendoza-Martínez, Isabel Vilaseca, Carl Llor   +8 more
openalex   +2 more sources

American College of Sports Medicine position stand. Exercise and physical activity for older adults.

Medicine & Science in Sports & Exercise, 2009
W. Chodzko-Zajko, D. Proctor, M. Fiatarone Singh, C. Minson, C. Nigg, G. Salem, J. Skinner   +6 more
semanticscholar   +1 more source