Results 111 to 120 of about 137,969 (305)

Novel approach to advance directive training: Hospice and palliative care fellow led workshop feasible and effective in increasing confidence in end of life conversations.

PLoS ONE
Despite the benefits of Advance directives, approximately only 1 in 3 U.S adults have documented advance directives. In medical school and residency, learners are often not taught or given very brief information on conducting end-of-life planning ...
Chelsea Chang, Jose Cano, Juan Lopez-Alvarenga, Josenny Rodriguez-Paez, Sonya Montes, Rosa White, Meghana Rao   +6 more
doaj   +1 more source

Junior medical doctors' decision making when using advance care directives to guide treatment for people with dementia: a cross-sectional vignette study. [PDF]

BMC Med Ethics, 2022
Waller A, Bryant J, Bowman A, White BP, Willmott L, Pickles R, Hullick C, Price E, Knight A, Ryall MA, Clapham M, Sanson-Fisher R.   +11 more
europepmc   +1 more source

Should Aggregate Patient Preference Data Be Used to Make Decisions on Behalf of Unrepresented Patients? [PDF]

, 2019
Patient preference predictors aim to solve the moral problem of making treatment decisions on behalf of incapacitated patients. This commentary on a case of an unrepresented patient at the end of life considers 3 related problems of such ...
Sharadin, Nathaniel
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Am J Prev Med [PDF]

BackgroundCurrent, ongoing national surveys do not include questions about end-of-life (EOL) issues. In particular, population-based data are lacking regarding the factors associated with advance directive completion.PurposeTo characterize U.S.

core  

Advance directive and preference of old age home residents for community model of end-of-life care in Hong Kong [PDF]

, 2011
Key Messages: 1. Among 1600 cognitively normal elderly persons living in old age homes in Hong Kong, 88% preferred palliative treatments that could keep them comfortable and free from pain, and 88% agreed to have advance directives. Factors that favour
Chiu, PKC, Chu, LW, Hui, E, Kwok, T, Lee, DTF, Luk, JKH, McGhee, SM, Woo, J   +7 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Awareness and Attitudes towards Advance Care Directives (ACDs): An Online Survey of Portuguese Adults. [PDF]

Healthcare (Basel), 2021
Laranjeira C, Dixe MDA, Gueifão L, Caetano L, Passadouro R, Querido A.   +5 more
europepmc   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Advance Directives among Elderly Population: A Malaysian Experience

Journal of the Indian Academy of Geriatrics, 2017
Objective: As not many studies have been done on the topic of advance directives in Malaysia and it has yet to gain awareness among our population, we realised the need for a study to be done not only to delineate the prevalence and preference but also ...
T L Koh, C S Lei, T R Tajudin, Z Abdulshakur   +3 more
doaj