Results 111 to 120 of about 4,825,638 (305)
, 1993 In sum, advance directives have been proposed as the answer to the problem of how to empower patients so that they maintain control of their care even when incompetent. We have not yet shown that directives will answer that need. Indeed, the question may
Teno, Joan M., Lynn, Joanne
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Awareness and Attitudes towards Advance Care Directives (ACDs): An Online Survey of Portuguese Adults. [PDF]
Healthcare (Basel), 2021 Laranjeira C +5 more
europepmc +1 more source
Roles of Physicians, Attorneys, and Illness Experience in Advance Directives
, 1999 BACKGROUND: Age, illness severity, functional status, and education are associated with advance directive completion. We examined these patient characteristics and discussions with attorneys and physicians in a predictive model for advance directive ...
Kazis, Lewis +3 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Sorting Out Advance Directives
, 2011 Important differences exist in advance directives.
Dimick, Chris
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Advance Care Directives Among a Population-Based Sample of Young Adults with Congenital Heart Defects, CH STRONG, 2016-2019. [PDF]
Pediatr Cardiol, 2021 Farr SL +5 more
europepmc +1 more source
Advanced Directives in Primary Care
, 2017 The disclosure of information to patients on the subject of code status is variable as there is a lack of evidence based practice or standardized disclosure of information. Multiple articles and studies have been reviewed which illustrate such a deficit but do not indicate how to either create or implement evidence-based practice to address this ...
openaire +2 more sources