Results 131 to 140 of about 4,825,638 (305)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Comparisons of research trends and hot areas between China and America in advance care planning based on Web of Science and CNKI database

Huli yanjiu, 2020
ObjectiveUsing knowledge mapping technology,to probe into the similarities and differences of the research trends in advance care planning between China and America,and to analyze the Chinese characteristics.MethodsLiteratures related to advance care ...
ZHU Tingting, LIU Dongling, ZHANG Jing, GAO Qiaoqiao, WANG Zichen, LI Jiayin, LIU Xuebing   +6 more
doaj  

Multivariate analysis of factors associated with advance directives completion among patients with advance care planning communication.

, 2018
Multivariate analysis of factors associated with advance directives completion among patients with advance care planning communication.
Li-Ying Huang (746473), Dachen Chu (639442), J. Randall Curtis (5488076), Wen-Jung Sun (5488085), Yun-Ju Lai (599120), Chu-Chieh Chen (5310392), Sheng-Jean Huang (5488079), Ming-Chung Ko (5488082), Ya-Ling Lee (639441), Hsiao-Yun Hu (524410), Yung-Feng Yen (488830)   +10 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Older People's Responses to Education About Advance Directives

, 1995
As advances in medical technology increase the life span, social workers committed to quality of life for elderly people are faced with practice challenges.
DePoy, Elizabeth, Bailly, Deborah J.
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Advance Directives on Admission: Clinical Implications and Analysis of the Patient Self-Determination Act of 1990

, 1991
To encourage patients to complete advance directives, Congress enacted the Patient Self-Determination Act...last October. The Act takes effect on December 1, 1991, and requires hospitals, nursing homes, and hospices to advise patients on admission of ...
Moss, Robert J., La Puma, John, Orentlicher, David   +2 more
core  

Univariate analysis of factors associated with advance directives completion among patients with advance care planning communication.

, 2018
Univariate analysis of factors associated with advance directives completion among patients with advance care planning communication.
Li-Ying Huang (746473), Dachen Chu (639442), J. Randall Curtis (5488076), Wen-Jung Sun (5488085), Yun-Ju Lai (599120), Chu-Chieh Chen (5310392), Sheng-Jean Huang (5488079), Ming-Chung Ko (5488082), Ya-Ling Lee (639441), Hsiao-Yun Hu (524410), Yung-Feng Yen (488830)   +10 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source