Results 191 to 200 of about 137,565 (304)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

COVID-19 in Older Adults: Transfers Between Nursing Homes and Hospitals [PDF]

, 2020
Bonner, Alice, Levine, Stacie, Melady, Donald, Perry, Adam, Unroe, Kathleen T.   +4 more
core  

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Enhancing Advance Directive Completion Among Older Adults in the Geriatrics Clinic in Indiana, USA: A Quality Improvement Initiative. [PDF]

Healthcare (Basel)
Guillen AGP, Recarte TA, Castillo MP, Ramirez MEZ, Mártir JFS.   +4 more
europepmc   +1 more source

END-OF-LIFE CARE AND ADVANCE DIRECTIVES IN JAPAN [PDF]

ハットリ, トシコ, 服部, 俊子
core  

Start the Conversation: National Healthcare Decisions Day [PDF]

, 2012
Kornblatt, Lynn R., Esq., Phipps, Etienne, PhD   +1 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Grace at the End of Life: Rethinking Ordinary and Extraordinary Means in a Global Context [PDF]

, 2019
Kelly, Conor M.
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Interdisciplinary Training to Enhance Home Health Clinician Knowledge of Palliative Care: Findings from the PIVOT Pilot Study. [PDF]

J Palliat Med
Patel C, Wilson CM, Lum HD, Huebschmann A, Tietbohl C, Budnikova T, Ruvins G, Jones CD.   +7 more
europepmc   +1 more source