Results 81 to 90 of about 137,565 (304)

Planning After Stroke Survival: Advance Care Planning in the Stroke Clinic

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Stroke survivors have high rates of mortality and recurrent stroke. Stroke patients are often unable to participate in decision making, highlighting the need for advance care planning (ACP) in poststroke care.
Paul D. Johnson, Angela Ulrich, Jenny Siv, Breana Taylor, David Tirschwell, Claire J. Creutzfeldt   +5 more
doaj   +1 more source

Understanding Advance Directives as a Component of Advance Care Planning

The American Journal of Bioethics, 2020
Walsh (2020) presents an argument against what she calls the received view of advance directives in the philosophical literature, suggesting instead a view that she believes is supported by “real c...
Kristina Celeste Fong, Winston Chiong
openaire   +4 more sources

End-of-life care and dementia [PDF]

, 2006
In the UK, research continues to confirm that people with certain chronic illnesses, such as chronic lung disease and cardiac failure, represent the ‘disadvantaged dying’ compared to those with terminal cancer.
Ballard, Clive, Daley, Sarah, Hughes, Julian, Keady, John, Robinson, Louise, Volicer, Ladislav   +5 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Bioethical and medico-legal implications of withdrawing artificial nutrition and hydration from adults in critical care [PDF]

, 2015
The withdrawal of artificial nutrition and hydration or other life-sustaining treatments is a clinical decision, made in ICUs or in other settings, involving patients suffering from serious and irreversible diseases or impaired consciousness.
A Qaseem, American Academy of Neurology, Executive Board, American Council on Ethical and Judicial Affairs, B Jennett, B Solarino, British Medical Association, C Moreschi, DB Dill, DI Katz, DS Diekema, DT Wade, E Tsai, ER Nadel, GD Rubenfeld, HB Simon, HM Buiting, HRW Pasman, J Barr, JE Ellershaw, JE Perry, JHT Karlawish, K Faber-Langendoen, K Puntillo, L Snyder, M Rosanova, MD Siegel, NB Strydom, P Kerndt, R Lehembre, RD Truog, RM McCann, S Moratti, S Winter, SB Harvey, U Korner, V Bonito, WB Breitbart, Y Shapiro   +37 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Advance directive and preference of old age home residents for community model of end-of-life care in Hong Kong [PDF]

, 2011
Key Messages: 1. Among 1600 cognitively normal elderly persons living in old age homes in Hong Kong, 88% preferred palliative treatments that could keep them comfortable and free from pain, and 88% agreed to have advance directives. Factors that favour
Chiu, PKC, Chu, LW, Hui, E, Kwok, T, Lee, DTF, Luk, JKH, McGhee, SM, Woo, J   +7 more
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Advance directives from haematology departments: the patient’s freedom of choice and communication with families. A qualitative analysis of 35 written documents

BMC Palliative Care, 2018
Background In France, advance directives are favourably perceived by most of the population, although the drafting rate is low. This ambivalence is challenging because advance directives are meant to promote the autonomy and freedom of choice of patients.
S. Trarieux-Signol, D. Bordessoule, J. Ceccaldi, S. Malak, A. Polomeni, J. B. Fargeas, N. Signol, H. Pauliat, S. Moreau   +8 more
doaj   +1 more source