Results 71 to 80 of about 939,645 (297)

Comparisons of research trends and hot areas between China and America in advance care planning based on Web of Science and CNKI database

Huli yanjiu, 2020
ObjectiveUsing knowledge mapping technology,to probe into the similarities and differences of the research trends in advance care planning between China and America,and to analyze the Chinese characteristics.MethodsLiteratures related to advance care ...
ZHU Tingting, LIU Dongling, ZHANG Jing, GAO Qiaoqiao, WANG Zichen, LI Jiayin, LIU Xuebing   +6 more
doaj  

Early advance care planning in amyotrophic lateral sclerosis patients: results of a systematic intervention by a palliative care team in a multidisciplinary management programme – a 4-year cohort study

Swiss Medical Weekly, 2021
INTRODUCTION Although recommended, the implementation of early advance care planning is suboptimal in amyotrophic lateral sclerosis (ALS) patients.
Eglė Sukockienė, Ruxandra Iancu-Ferfoglia, Monique Boegli, Catherine Lefranc-Barranco, André Truffert, Anne-Chantal Héritier-Barras, Laurence Genton, Igor Leuchter, Dan Adler, Jean-Paul Janssens, Monica Escher   +10 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Documenting plans for care: advance care directives and the 7-step pathway in the acute care context

BMC Palliative Care, 2021
Background Advance care planning involves the discussion and documentation of an individual’s values and preferences to guide their future healthcare should they lose capacity to make or communicate treatment decisions.
Gregory Brian Crawford, Katherine Hodgetts, Teresa Burgess, Jaklin Eliott   +3 more
doaj   +1 more source

Evaluation of the advance/anticipatory care planning (ACP) facilitators training programme [PDF]

, 2011
This report presents an overview of the findings of the three phases of the study and assesses the degree to which the Facilitator Training Programme and Resource Pack have prepared the cohort of facilitators with the knowledge, skills and tools to ...
Ferguson, R, Harris, Rachel A
core  

Provider Perspectives on the Influence of Family on Nursing Home Resident Transfers to the Emergency Department: Crises at the End of Life. [PDF]

, 2015
Background. Nursing home (NH) residents often experience burdensome and unnecessary care transitions, especially towards the end of life. This paper explores provider perspectives on the role that families play in the decision to transfer NH residents to
Bui, Nhat, Halifax, Elizabeth, Harrington, Charlene, Lee, Sei J, Ritchie, Christine, Shim, Janet, Stephens, Caroline   +6 more
core   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Meeting the challenge of diabetes in ageing and diverse populations: a review of the literature from the UK [PDF]

, 2016
The impact of type 2 diabetes on ageing societies is great and populations across the globe are becoming more diverse. Complications of diabetes unequally affect particular groups in the UK older people, and people with a South Asian background are two ...
Randhawa, Gurch, Sinclair, Alan J., Waqar, Muhammad, Wilkinson, Emma   +3 more
core   +5 more sources