Results 91 to 100 of about 939,645 (297)

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A healthcare provider perspective in overcoming the psychological and emotional barriers of advance care planning: The need to normalize the conversation [PDF]

, 2018
Barriers to advance care planning in the patient population were explored. The need to normalize the conversation was identified.
Danyal, Karamatullah
core   +1 more source

Developing a service for patients with very severe chronic obstructive pulmonary disease (COPD) within resources [PDF]

, 2013
Chronic obstructive pulmonary disease (COPD) is a common life-limiting illness with significant burden for patient and carer. Despite this, access to supportive and specialist palliative care is inconsistent and implementation of published good practice ...
Ainscough, Rachel, Boland, Jason, Mahdi, Hazim, Owen, Janet   +3 more
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Mapping advance care planning and advance directives in Latin America

BMC Palliative Care
Background/aims The extent to which low- and middle-income countries have implemented Advance Care Planning (ACP) and Advance Directives (AD) remains unclear. We aimed to map the current status of ACP/AD in Latin America.
Natália Rocha Tardelli, Fernanda Bono Fukushima, Jenny T. van der Steen, Manuel Iván Cobas Rodríguez, Rasa Mikelyte, Daniel Neves Forte, Alex Sander Watanabe Palácio, Vilma Adriana Tripodoro, Mirna Garcia Burgoa, Douglas Henrique Crispim, Alfredo Rodríguez-Núñez, Luis Ricardo González Cruz, Mariuska Forteza Sáez, Patricia Bonilla Sierra, Ancu Tatiana Feng Escobar, María Elena del Rosario Alcántara Godoy, Tulio Enrique Velásquez Castellanos, Mónica Osio Saldaña, Nisla Camaño Reyes, Miriam Elisa Riveros Ríos, Maria del Rosario Berenguel Cook, Gloria Castillo Pichardo, Carlos Fernando Acuña Aguilar, Gabriela Píriz Alvarez, Ismariel Inés Espín Gonzalez, Leonardo de Andrade Rodrigues Brito, Edison Iglesias de Oliveira Vidal   +26 more
doaj   +1 more source

Willingness to provide advance care planning in hospital setting: a cross-sectional survey

Palliative Medicine in Practice
BACKGROUND: To assess the willingness to provide advance directives (AD) and evaluate the association of sociodemographic and cultural factors in hospitalized patients in a general ward.
Diego Caruso, Maria Pia Izaguirre Germain, Natasha Velcoff, Berenice Casas, Matias Zamudio, Feridco Sena, Josefina Velasco, Mary Berzain Rodriguez, Fernando Ross   +8 more
doaj   +1 more source

The economic evidence for advance care planning: systematic review of evidence [PDF]

, 2015
Background: Advance care planning (ACP), a process of discussion and review concerning future care in the event of losing capacity. Aimed at improving the appropriateness and quality of care, it is also often considered a means of controlling health ...
Dixon, Josie, Knapp, Martin, Matosevic, Tihana   +2 more
core   +1 more source

Content analysis of Advance Directives completed by patients with advanced cancer as part of an Advance Care Planning intervention : insights gained from the ACTION trial [PDF]

, 2020
Purpose Writing an Advance Directive (AD) is often seen as a part of Advance Care Planning (ACP). ADs may include specific preferences regarding future care and treatment and information that provides a context for healthcare professionals and relatives ...
Caswell, G, Deliens, Luc, Ingravallo, F, Jabbarian, LJ, Johnsen, AT, Kars, MC, Korfage, IJ, Mimić, A, Møller Arnfeldt, C, Preston, NJ, van Delden, JJM, Zwakman, Marieke   +11 more
core   +4 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source