Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Sex differences in advance directives and their clinical translation among critically ill adults: results from the ADVISE study. [PDF]
Ann Intensive CareAmacher SA +12 more
europepmc +1 more source
Factors That Influence Attitudes toward Advance Directives among Female Cancer Patients. [PDF]
J Hosp Palliat Care, 2023 Kim A, Kim K.
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Effect of an app for promoting advance care planning and motivating patients to write their advance directives. [PDF]
BMC Health Serv Res, 2023 Schöpfer C +4 more
europepmc +1 more source
Prevalence and Contents of Advance Directives of Patients with ESRD Receiving Dialysis [PDF]
, 2016 Molly A. Feely +3 more
openalex +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Preparing for the end-of-life: public attitudes towards advance directives and assisted suicide in Switzerland. [PDF]
BMC Palliat CareBlanc S +4 more
europepmc +1 more source
Novel Approach to Advance Directive Training: Palliative Fellow Led Workshop Feasible and Effective in Increasing Confidence in End of Life Conversations [PDF]
Chelsea Chang +5 more
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source