Results 231 to 240 of about 1,191,211 (370)

Advance Directive

, 2014
Hitoshi Arima, Akira Akabayashi
openaire   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Advance directives in amyotrophic lateral sclerosis - a systematic review and meta-analysis. [PDF]

BMC Palliat Care
Mangal AL, Mücke M, Rolke R, Appelmann I.   +3 more
europepmc   +1 more source

Knowledge, Experience, and Attitudes of Nurses at Long-Term Care Hospitals regarding Advance Directives. [PDF]

J Hosp Palliat Care, 2022
Park GE, Lee NY.
europepmc   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Acceptability and usability of the Planning Advance Care Together (PACT) website for improving patients' engagement in advance care planning

PEC Innovation
Objectives: Most prior advance care planning (ACP) interventions lack integration of the social context of patients' ACP process, which patients indicate is critically important.
Casey A. Walsh, Sarah J. Miller, Cardinale B. Smith, Holly G. Prigerson, Daniel McFarland, Sarah Yarborough, Claudia De Los Santos, Robert Thomas, Sara J. Czaja, Arindam RoyChoudhury, Eloise Chapman-Davis, Mark Lachs, Megan J. Shen   +12 more
doaj  

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Advance directives in the emergency department-a systematic review of the status quo. [PDF]

BMC Health Serv Res
Weber V, Hübner A, Pflock S, Schamberger L, Somasundaram R, Boehm L, Bauer W, Diehl-Wiesenecker E.   +7 more
europepmc   +1 more source

Preparing for the End of Life: Medical Students Completing Their Own Advance Directives Described Increased Empathy for Patients. [PDF]

Fam Med, 2023
Erlich D, Lee A, Duggan A, Walec K.
europepmc   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source